9k8y: Difference between revisions

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'''Unreleased structure'''


The entry 9k8y is ON HOLD
==Structure of PfENT1(T144C,K375C,N60R,Q266R) with inosine- outward-facing state==
 
<StructureSection load='9k8y' size='340' side='right'caption='[[9k8y]], [[Resolution|resolution]] 3.76&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9k8y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9K8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9K8Y FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.76&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NOS:INOSINE'>NOS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9k8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9k8y OCA], [https://pdbe.org/9k8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9k8y RCSB], [https://www.ebi.ac.uk/pdbsum/9k8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9k8y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENT1_PLAF7 ENT1_PLAF7] Sodium-independent nucleoside and nucleobase transporter with a broad substrate specificity (PubMed:10744765, PubMed:10861212, PubMed:16751273, PubMed:18639591, PubMed:36977719). Plays a key role in the utilization of host purine sources by P.falciparum during intraerythrocytic development enabling parasite growth in the presence of physiological concentrations of adenosine, inosine, guanine, guanosine, xanthine and hypoxanthine (PubMed:16751273, PubMed:18639591). Essential for parasite transition from ring to trophozoite or from trophozoite to schizont stage but not for erythrocyte invasion by merozoites (PubMed:16751273).<ref>PMID:10744765</ref> <ref>PMID:10861212</ref> <ref>PMID:16751273</ref> <ref>PMID:18639591</ref> <ref>PMID:36977719</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Chen XY]]
[[Category: Deng D]]
[[Category: Li JL]]
[[Category: Wang X]]
Retrieved from "https://proteopedia.org/9k8y"