9e6j: Difference between revisions
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==DH726-1 Fab bound to hemagglutinin from influenza A/Solomon Islands/3/2006== | |||
<StructureSection load='9e6j' size='340' side='right'caption='[[9e6j]], [[Resolution|resolution]] 2.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9e6j]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Alphainfluenzavirus_influenzae Alphainfluenzavirus influenzae] and [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9E6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9E6J FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.98Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9e6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9e6j OCA], [https://pdbe.org/9e6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9e6j RCSB], [https://www.ebi.ac.uk/pdbsum/9e6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9e6j ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A7UPX0_9INFA A7UPX0_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Alphainfluenzavirus influenzae]] | |||
[[Category: Large Structures]] | |||
[[Category: Macaca mulatta]] | |||
[[Category: Finney J]] | |||
[[Category: Harrison SC]] | |||
Latest revision as of 13:02, 10 February 2026
DH726-1 Fab bound to hemagglutinin from influenza A/Solomon Islands/3/2006
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