9gy0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The entry ~~9gy0 is ON HOLD until Paper Publication~~

==Cryo_EM structure of human FAN1 R507H mutant in complex with 5' flap DNA substrate and PCNA==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9gy0]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GY0 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9GY0 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.42Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9gy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gy0 OCA], [https://pdbe.org/9gy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gy0 RCSB], [https://www.ebi.ac.uk/pdbsum/9gy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gy0 ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Jeyasankar G]]

[[Category: Salerno-Kochan A]]

[[Category: Thomsen M]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9gy0 is ON HOLD  until Paper Publication
+==Cryo_EM structure of human FAN1 R507H mutant in complex with 5' flap DNA substrate and PCNA==
+<StructureSection load='9gy0' size='340' side='right'caption='[[9gy0]], [[Resolution|resolution]] 3.42&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9gy0]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GY0 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.42&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gy0 OCA], [https://pdbe.org/9gy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gy0 RCSB], [https://www.ebi.ac.uk/pdbsum/9gy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gy0 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Jeyasankar G]]
+[[Category: Salerno-Kochan A]]
+[[Category: Thomsen M]]