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[[Image:1u7k.jpg|left|200px]]
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{{STRUCTURE_1u7k|  PDB=1u7k  |  SCENE=  }}
'''Structure of a hexameric N-terminal domain from murine leukemia virus capsid'''


==Structure of a hexameric N-terminal domain from murine leukemia virus capsid==
<StructureSection load='1u7k' size='340' side='right'caption='[[1u7k]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1u7k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/AKR_(endogenous)_murine_leukemia_virus AKR (endogenous) murine leukemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U7K FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u7k OCA], [https://pdbe.org/1u7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u7k RCSB], [https://www.ebi.ac.uk/pdbsum/1u7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u7k ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u7/1u7k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u7k ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Retroviruses are the aetiological agents of a range of human diseases including AIDS and T-cell leukaemias. They follow complex life cycles, which are still only partly understood at the molecular level. Maturation of newly formed retroviral particles is an essential step in production of infectious virions, and requires proteolytic cleavage of Gag polyproteins in the immature particle to form the matrix, capsid and nucleocapsid proteins present in the mature virion. Capsid proteins associate to form a dense viral core that may be spherical, cylindrical or conical depending on the genus of the virus. Nonetheless, these assemblies all appear to be composed of a lattice formed from hexagonal rings, each containing six capsid monomers. Here, we describe the X-ray structure of an individual hexagonal assembly from N-tropic murine leukaemia virus (N-MLV). The interface between capsid monomers is generally polar, consistent with weak interactions within the hexamer. Similar architectures are probably crucial for the regulation of capsid assembly and disassembly in all retroviruses. Together, these observations provide new insights into retroviral uncoating and how cellular restriction factors may interfere with viral replication.


==Overview==
High-resolution structure of a retroviral capsid hexameric amino-terminal domain.,Mortuza GB, Haire LF, Stevens A, Smerdon SJ, Stoye JP, Taylor IA Nature. 2004 Sep 23;431(7007):481-5. PMID:15386017<ref>PMID:15386017</ref>
Retroviruses are the aetiological agents of a range of human diseases including AIDS and T-cell leukaemias. They follow complex life cycles, which are still only partly understood at the molecular level. Maturation of newly formed retroviral particles is an essential step in production of infectious virions, and requires proteolytic cleavage of Gag polyproteins in the immature particle to form the matrix, capsid and nucleocapsid proteins present in the mature virion. Capsid proteins associate to form a dense viral core that may be spherical, cylindrical or conical depending on the genus of the virus. Nonetheless, these assemblies all appear to be composed of a lattice formed from hexagonal rings, each containing six capsid monomers. Here, we describe the X-ray structure of an individual hexagonal assembly from N-tropic murine leukaemia virus (N-MLV). The interface between capsid monomers is generally polar, consistent with weak interactions within the hexamer. Similar architectures are probably crucial for the regulation of capsid assembly and disassembly in all retroviruses. Together, these observations provide new insights into retroviral uncoating and how cellular restriction factors may interfere with viral replication.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1U7K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U7K OCA].
</div>
<div class="pdbe-citations 1u7k" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
High-resolution structure of a retroviral capsid hexameric amino-terminal domain., Mortuza GB, Haire LF, Stevens A, Smerdon SJ, Stoye JP, Taylor IA, Nature. 2004 Sep 23;431(7007):481-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15386017 15386017]
*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
[[Category: Single protein]]
== References ==
[[Category: Viruses]]
<references/>
[[Category: Haire, L F.]]
__TOC__
[[Category: Mortuza, G B.]]
</StructureSection>
[[Category: Smerdon, S J.]]
[[Category: Large Structures]]
[[Category: Stevens, A.]]
[[Category: Haire LF]]
[[Category: Stoye, J P.]]
[[Category: Mortuza GB]]
[[Category: Taylor, I A.]]
[[Category: Smerdon SJ]]
[[Category: Capsid]]
[[Category: Stevens A]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:51:28 2008''
[[Category: Stoye JP]]
[[Category: Taylor IA]]
Retrieved from "https://proteopedia.org/1u7k"