9hd0: Difference between revisions

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New page: '''Unreleased structure''' The entry 9hd0 is ON HOLD Authors: Casale, G., Le Bihan, Y.-V., van Montfort, R.L.M., Guettler, S. Description: Crystal structure of human TRF1 TRFH domain i...
 
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'''Unreleased structure'''


The entry 9hd0 is ON HOLD
==Crystal structure of human TRF1 TRFH domain in complex with compound 55==
 
<StructureSection load='9hd0' size='340' side='right'caption='[[9hd0]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
Authors: Casale, G., Le Bihan, Y.-V., van Montfort, R.L.M., Guettler, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9hd0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HD0 FirstGlance]. <br>
Description: Crystal structure of human TRF1 TRFH domain in complex with compound 55
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A9E:2-(4-ethylphenoxy)-1-piperidin-1-yl-ethanone'>A9E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[Category: Van Montfort, R.L.M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hd0 OCA], [https://pdbe.org/9hd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hd0 RCSB], [https://www.ebi.ac.uk/pdbsum/9hd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hd0 ProSAT]</span></td></tr>
[[Category: Guettler, S]]
</table>
[[Category: Le Bihan, Y.-V]]
== Function ==
[[Category: Casale, G]]
[https://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Casale G]]
[[Category: Guettler S]]
[[Category: Le Bihan Y-V]]
[[Category: Van Montfort RLM]]
Retrieved from "https://proteopedia.org/9hd0"