9hf2: Difference between revisions
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==CryoEM structure of dephosphorylated mouse Panx1== | |||
<StructureSection load='9hf2' size='340' side='right'caption='[[9hf2]], [[Resolution|resolution]] 4.68Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9hf2]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HF2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.68Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hf2 OCA], [https://pdbe.org/9hf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hf2 RCSB], [https://www.ebi.ac.uk/pdbsum/9hf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hf2 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PANX1_MOUSE PANX1_MOUSE] Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:30814251). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (PubMed:22311122). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed:32238926). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity).[UniProtKB:Q96RD7]<ref>PMID:22311122</ref> <ref>PMID:30814251</ref> <ref>PMID:32238926</ref> During apoptosis and after cleavage by caspases of the C-terminal tail, acts as a plasma membrane channel which mediates the regulated release of find-me signals, such as nucleotides ATP and UTP, and selective plasme membrane permeability.<ref>PMID:32238926</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Dahl G]] | |||
[[Category: Gaullier G]] | |||
[[Category: Mim C]] | |||
[[Category: Zhang Q]] | |||
Latest revision as of 06:19, 26 November 2025
CryoEM structure of dephosphorylated mouse Panx1
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