9hf4: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 9hf4 is ON HOLD Authors: Casale, G., Le Bihan, Y.-V., Van Montfort, R.L.M., Guettler, S. Description: Crystal structure of human TRF1 TRFH domain i... |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of human TRF1 TRFH domain in complex with compound 32== | |||
<StructureSection load='9hf4' size='340' side='right'caption='[[9hf4]], [[Resolution|resolution]] 2.17Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9hf4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HF4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IUC:4-phenylmethoxynaphthalene-1-sulfonic+acid'>A1IUC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hf4 OCA], [https://pdbe.org/9hf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hf4 RCSB], [https://www.ebi.ac.uk/pdbsum/9hf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hf4 ProSAT]</span></td></tr> | ||
[[Category: Casale | </table> | ||
[[Category: Guettler | == Function == | ||
[[Category: Van Montfort | [https://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Casale G]] | |||
[[Category: Guettler S]] | |||
[[Category: Le Bihan Y-V]] | |||
[[Category: Van Montfort RLM]] | |||
Latest revision as of 06:19, 26 November 2025
Crystal structure of human TRF1 TRFH domain in complex with compound 32
| ||||||||||||
