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'''Unreleased structure'''


The entry 9kjb is ON HOLD
==Crystal structure of Anti-CRISPR AcrIE7==
<StructureSection load='9kjb' size='340' side='right'caption='[[9kjb]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9kjb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KJB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kjb OCA], [https://pdbe.org/9kjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kjb RCSB], [https://www.ebi.ac.uk/pdbsum/9kjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kjb ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The CRISPR-Cas system is a well-known adaptive immune system in bacteria, and a prominent mechanism for evading this immunity involves anti-CRISPR (Acr) proteins, which employ various methods to neutralize the CRISPR-Cas system. In this study, using structural and biochemical analyses, we revealed that AcrIE7 binds to the single-stranded DNA in the R-loop formed when Cascade encounters the target DNA, thereby preventing Cas3 from cleaving the DNA. This represents a different inhibition strategy distinct from previously reported Acr mechanisms and offers insights into CRISPR-Cas inhibition.


Authors: Kim, D.Y., Park, H.H.
AcrIE7 inhibits the CRISPR-Cas system by directly binding to the R-loop single-stranded DNA.,Kim DY, Lee SY, Ha HJ, Park HH Proc Natl Acad Sci U S A. 2025 Apr 8;122(14):e2423205122. doi: , 10.1073/pnas.2423205122. Epub 2025 Apr 3. PMID:40178896<ref>PMID:40178896</ref>


Description: Crystal structure of Anti-CRISPR AcrIE7
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Kim, D.Y]]
<div class="pdbe-citations 9kjb" style="background-color:#fffaf0;"></div>
[[Category: Park, H.H]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Kim DY]]
[[Category: Park HH]]
Retrieved from "https://proteopedia.org/9kjb"