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New page: left|200px<br /> <applet load="1y02" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y02, resolution 1.8Å" /> '''Crystal Structure of...
 
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[[Image:1y02.gif|left|200px]]<br />
<applet load="1y02" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1y02, resolution 1.8&Aring;" />
'''Crystal Structure of a FYVE-type domain from caspase regulator CARP2'''<br />


==Overview==
==Crystal Structure of a FYVE-type domain from caspase regulator CARP2==
The caspase-associated ring proteins (CARP1 and CARP2) are distinguished, from other caspase regulators by the presence of a FYVE-type zinc finger, domain. FYVE-type domains are divided into two known classes: FYVE domains, that specifically bind to phosphatidylinositol 3-phosphate in lipid, bilayers and FYVE-related domains of undetermined function. Here, we, report the crystal structure of the N-terminal region of CARP2 (44-139), including the FYVE-type domain and its associated helical bundle at 1.7 A, resolution. The structure reveals a cramped phosphoinositide binding, pocket and a blunted membrane insertion loop. These structural features, indicate that the domain is not optimized to bind to phosphoinositides or, insert into lipid bilayers. The CARP2 FYVE-like domain thus defines a, third subfamily of FYVE-type domains that are functionally and, structurally distinct. Structural analyses provide insights into the, possible function of this unique subfamily of FYVE-type domains.
<StructureSection load='1y02' size='340' side='right'caption='[[1y02]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1y02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y02 FirstGlance]. <br>
1Y02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Y02 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y02 OCA], [https://pdbe.org/1y02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y02 RCSB], [https://www.ebi.ac.uk/pdbsum/1y02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y02 ProSAT]</span></td></tr>
Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2., Tibbetts MD, Shiozaki EN, Gu L, McDonald ER 3rd, El-Deiry WS, Shi Y, Structure. 2004 Dec;12(12):2257-63. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15576038 15576038]
</table>
== Function ==
[https://www.uniprot.org/uniprot/RFFL_HUMAN RFFL_HUMAN] Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.<ref>PMID:15069192</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y02_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y02 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Gu, L.]]
[[Category: Gu L]]
[[Category: Shi, Y.]]
[[Category: Shi Y]]
[[Category: Shiozaki, E.N.]]
[[Category: Shiozaki EN]]
[[Category: Tibbetts, M.D.]]
[[Category: Tibbetts MD]]
[[Category: ZN]]
[[Category: carp2]]
[[Category: caspase regulation]]
[[Category: fyve]]
[[Category: phosphoinositide binding]]
[[Category: zinc-binding module]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:12:59 2007''

Latest revision as of 08:54, 14 February 2024

Crystal Structure of a FYVE-type domain from caspase regulator CARP2

1y02, resolution 1.80Å

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