9hlc: Difference between revisions
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The entry | ==TRPML1 in complex with compound 11== | ||
<StructureSection load='9hlc' size='340' side='right'caption='[[9hlc]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9hlc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HLC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8K6:OCTADECANE'>8K6</scene>, <scene name='pdbligand=A1IV5:(8~{R},9~{S},13~{S},14~{S},17~{S})-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol'>A1IV5</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=EUJ:[(2~{R})-2-octanoyloxy-3-[oxidanyl-[(2~{R},3~{R},5~{S},6~{R})-2,4,6-tris(oxidanyl)-3,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl]+octanoate'>EUJ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hlc OCA], [https://pdbe.org/9hlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hlc RCSB], [https://www.ebi.ac.uk/pdbsum/9hlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hlc ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN] Mucolipidosis type 4. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN] Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.<ref>PMID:12459486</ref> <ref>PMID:14749347</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Clark M]] | |||
[[Category: Cowan SR]] | |||
[[Category: Di Daniel E]] | |||
[[Category: Earl CP]] | |||
[[Category: Fisher S]] | |||
[[Category: Holvey RS]] | |||
[[Category: Jackson SM]] | |||
[[Category: Johnson CN]] | |||
[[Category: Lloyd-Evans E]] | |||
[[Category: Mahajan P]] | |||
[[Category: Morgillo CM]] | |||
[[Category: Mortenson PN]] | |||
[[Category: O'Reilly M]] | |||
[[Category: Reeks J]] | |||
[[Category: Richardson CJ]] | |||
[[Category: Schopf P]] | |||
[[Category: Tams DM]] | |||
[[Category: Waller-Evans H]] | |||
[[Category: Ward SE]] | |||
[[Category: Whibley S]] | |||
[[Category: Williams PA]] | |||
Latest revision as of 08:29, 4 June 2025
TRPML1 in complex with compound 11
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