9hmd: Difference between revisions
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New page: '''Unreleased structure''' The entry 9hmd is ON HOLD Authors: Zhang, R., Waldmann, H., Gasper, R. Description: Crystal structure of PDE6D in complex with DeltaTag (6a) [[Category: Unre... |
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==Crystal structure of PDE6D in complex with DeltaTag (6a)== | |||
<StructureSection load='9hmd' size='340' side='right'caption='[[9hmd]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9hmd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HMD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IWD:4-[3,4-dimethyl-2-(4-methylphenyl)-7-oxidanylidene-pyrazolo[3,4-d]pyridazin-6-yl]-~{N}-[2-(3-ethylphenyl)ethyl]-~{N}-(piperidin-4-ylmethyl)butane-1-sulfonamide'>A1IWD</scene></td></tr> | ||
[[Category: Gasper | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hmd OCA], [https://pdbe.org/9hmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hmd RCSB], [https://www.ebi.ac.uk/pdbsum/9hmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hmd ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Gasper R]] | |||
[[Category: Waldmann H]] | |||
[[Category: Zhang R]] | |||
Latest revision as of 05:11, 24 December 2025
Crystal structure of PDE6D in complex with DeltaTag (6a)
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