9how: Difference between revisions

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~~'''Unreleased structure'''~~

~~The~~ entry ~~9how~~ is ~~ON HOLD~~

==Variant K314R of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in resting state==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9how]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HOW OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9HOW FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9how FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9how OCA], [https://pdbe.org/9how PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9how RCSB], [https://www.ebi.ac.uk/pdbsum/9how PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9how ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>

== Function ==

[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Kirck LL]]

[[Category: Tittmann K]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9how is ON HOLD
+==Variant K314R of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in resting state==
+<StructureSection load='9how' size='340' side='right'caption='[[9how]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9how]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HOW FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9how FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9how OCA], [https://pdbe.org/9how PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9how RCSB], [https://www.ebi.ac.uk/pdbsum/9how PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9how ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Kirck LL]]
+[[Category: Tittmann K]]