9hj8: Difference between revisions

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'''Unreleased structure'''


The entry 9hj8 is ON HOLD  until Paper Publication
==TRPML1 in complex with compound 5==
 
<StructureSection load='9hj8' size='340' side='right'caption='[[9hj8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9hj8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HJ8 FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IVD:~{N},~{N}-dimethyl-4-[1-[2,2,2-tris(fluoranyl)ethyl]spiro[2~{H}-indole-3,4-piperidine]-1-yl]sulfonyl-benzenesulfonamide'>A1IVD</scene>, <scene name='pdbligand=EUJ:[(2~{R})-2-octanoyloxy-3-[oxidanyl-[(2~{R},3~{R},5~{S},6~{R})-2,4,6-tris(oxidanyl)-3,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl]+octanoate'>EUJ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hj8 OCA], [https://pdbe.org/9hj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hj8 RCSB], [https://www.ebi.ac.uk/pdbsum/9hj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hj8 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN] Mucolipidosis type 4. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN] Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.<ref>PMID:12459486</ref> <ref>PMID:14749347</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Clark M]]
[[Category: Cowan SR]]
[[Category: Di Daniel E]]
[[Category: Earl CP]]
[[Category: Fisher S]]
[[Category: Holvey RS]]
[[Category: Jackson SM]]
[[Category: Johnson CN]]
[[Category: Lloyd-Evans E]]
[[Category: Mahajan P]]
[[Category: Morgillo CM]]
[[Category: Mortenson PN]]
[[Category: O'Reilly M]]
[[Category: Reeks J]]
[[Category: Richardson CJ]]
[[Category: Schopf P]]
[[Category: Tams DM]]
[[Category: Waller-Evans H]]
[[Category: Ward SE]]
[[Category: Whibley S]]
[[Category: Williams PA]]
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