9l61: Difference between revisions
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New page: '''Unreleased structure''' The entry 9l61 is ON HOLD Authors: Jwala, N., Vijayshankar, N., Thomas, A., NarasimhaRao, K. Description: Crystal Structure of BRD2 BD2 domain in complex wit... |
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==Crystal Structure of BRD2 BD2 domain in complex with small molecule inhibitor Mivebresib ABBV-075== | |||
<StructureSection load='9l61' size='340' side='right'caption='[[9l61]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9l61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L61 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8NG:~{N}-[4-[2,4-bis(fluoranyl)phenoxy]-3-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide'>8NG</scene></td></tr> | ||
[[Category: Jwala | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l61 OCA], [https://pdbe.org/9l61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l61 RCSB], [https://www.ebi.ac.uk/pdbsum/9l61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l61 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Jwala N]] | |||
[[Category: NarasimhaRao K]] | |||
[[Category: Thomas A]] | |||
[[Category: Vijayshankar N]] | |||
Latest revision as of 05:16, 24 December 2025
Crystal Structure of BRD2 BD2 domain in complex with small molecule inhibitor Mivebresib ABBV-075
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