Semaglutide: Difference between revisions

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<text>☼</text>
<text>☼</text>
</jmolLink>
</jmolLink>
</jmol>) of the peptide agonist binds deeply into the transmembrane portion while the C-terminal residues (<jmol>
</jmol>) of the peptide agonist bind deeply into the transmembrane portion while the C-terminal residues (<jmol>
<jmolLink>
<jmolLink>
<script>
<script>
moveto 0.5 { -177 533 827 176.47} 305.9 0.0 0.0 {100.67477777777776 116.59377777777777 171.48799999999997} 123.29278847940834 {0 0 0} 0 0 0 3.0 0.0 0.0;
define current selected;
define current selected;
select 27-37 and chain=P;  
select 27-37 and chain=P;  
selectionHalos on;  
selectionHalos on;  
delay 0.5;  
delay 1.0;  
selectionHalos off;
selectionHalos off;
select current;
select current;
Line 47: Line 48:
<jmolLink>
<jmolLink>
<script>
<script>
moveto 0.5 { -116 -575 -810 168.51} 1237.54 0.0 0.0 {100.67477777777776 116.59377777777777 171.48799999999997} 123.29278847940834 {0 0 0} 0 0 0 3.0 0.0 0.0;
define current selected;
define current selected;
select 26:P;  
select 26:P;  
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<jmolLink>
<jmolLink>
<script>
<script>
moveto 0.3 { -116 -575 -810 168.51} 1237.54 -23.77 -24.63 {100.67477777777776 116.59377777777777 171.48799999999997} 123.29278847940834 {0 0 0} 0 0 0 3.0 0.0 0.0;
define current selected;
define current selected;
select 101:P;  
select 101:P;  
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</jmol>) to be attached without interfering with receptor binding.
</jmol>) to be attached without interfering with receptor binding.


Interactions of the <scene name='10/1062575/Semaglutide_and_receptor/4'>C-terminal part of semaglutide with the extracellular domain</scene> include a hydrophobic patch (<jmol>
Interactions of the <jmol>
<jmolLink>
<script>
moveto 1.0 { -864 363 349 132.79} 1354.39 0.0 0.0 {99.33772727272726 108.23119318181817 176.4468181818181} 129.71704236754204 {0 0 0} 0 0 0 3.0 0.0 0.0;
script /scripts/10/1062575/Semaglutide_and_receptor/4.spt
</script>
<text>C-terminal part of semaglutide with the extracellular domain</text>
</jmolLink>
</jmol>include a hydrophobic patch (<jmol>
<jmolLink>
<jmolLink>
<script>
<script>
moveto 0.5 { -654 447 610 145.0} 1024.11 0.0 0.0 {99.33772727272726 108.23119318181817 176.4468181818181} 129.71704236754204 {0 0 0} 0 0 0 3.0 0.0 0.0;
define current selected;
define current selected;
select ((28,29, 31,32) and chain=P) or ((39,88-91, 214) and chain=R)
select ((28,29, 31,32) and chain=P) or ((39,88-91, 214) and chain=R)
Line 86: Line 98:
<jmolLink>
<jmolLink>
<script>
<script>
moveto 1.0 { -861 293 415 125.65} 1024.11 6.0 15.44 {99.33772727272726 108.23119318181817 176.4468181818181} 129.71704236754204 {0 0 0} 0 0 0 3.0 0.0 0.0;
define current selected;
define current selected;
select 36:P or 68:R;
select 36:P or 68:R;
Line 96: Line 109:
<text>☼</text>
<text>☼</text>
</jmolLink>
</jmolLink>
</jmol>), and hydrogen bonds. Interactions of the <scene name='10/1062575/Semaglutide_and_receptor/7'>N-terminal domain of semaglutide with the transmembrane helices</scene> are extensive, including a hydrophobic patch in the receptor accommodating phenylalanine 12 (<jmol>
</jmol>), and hydrogen bonds. Interactions of the <jmol>
<jmolLink>
<jmolLink>
<script>
<script>
moveto 1.0 { -912 297 281 124.97} 726.1 -1.14 -11.14 {109.93813084112149 120.8334205607477 156.36937383177562} 106.47485918259859 {0 0 0} 0 0 0 3.0 0.0 0.0;
script /scripts/10/1062575/Semaglutide_and_receptor/7.spt
</script>
<text>N-terminal domain of semaglutide with the transmembrane helices</text>
</jmolLink>
</jmol> are extensive, including a hydrophobic patch in the receptor accommodating phenylalanine 12 (<jmol>
<jmolLink>
<script>
moveto 1.0 { -977 186 104 122.83} 726.1 -1.14 -11.14 {109.93813084112149 120.8334205607477 156.36937383177562} 106.47485918259859 {0 0 0} 0 0 0 3.0 0.0 0.0;
define current selected;
define current selected;
select 12:P;  
select 12:P;  
Line 112: Line 134:
<jmolLink>
<jmolLink>
<script>
<script>
moveto 1.0 { -685 -507 -522 122.57} 726.1 -1.39 -28.05 {109.93813084112149 120.8334205607477 156.36937383177562} 106.47485918259859 {0 0 0} 0 0 0 3.0 0.0 0.0;
define current selected;
define current selected;
select 7:P or 234:R or 241:R;  
select 7:P or 234:R or 241:R;  
Line 125: Line 148:
<jmolLink>
<jmolLink>
<script>
<script>
moveto 1.0 { -969 -113 -218 100.02} 1104.31 -7.13 -63.05 {109.93813084112149 120.8334205607477 156.36937383177562} 106.47485918259859 {0 0 0} 0 0 0 3.0 0.0 0.0;
define current selected;
define current selected;
select 9:P or 190:R;  
select 9:P or 190:R;  
Line 180: Line 204:


==Medical use of Semaglutide==
==Medical use of Semaglutide==
Semaglutide medications (Ozempic, Wegovy, and Rybelsus) have become extremely popular over time in managing weight loss and obesity. Originally developed as treatments for type 2 diabetes, medications such as Ozempic are now widely used for their ability to aid weight loss. As a GLP-1 receptor agonist (GLP-1 RA), semaglutide works by mimicking the effects of the GLP-1 hormone in the body. This action helps regulate the metabolic system, control appetite, and reduce calorie intake, leading to significant weight loss in many users. Semaglutide also slows gastric emptying, which prolongs the feeling of fullness after eating and further supports weight management. 
Semaglutide medications (Ozempic, Wegovy, and Rybelsus) have become extremely popular over time in managing weight loss and obesity. A KFF poll conducted in May 2024 found that 1 in 8 respondents (adults in the United States) say that they have taken a GLP-1 agonist in the past <ref>Harris E. Poll: Roughly 12% of US Adults Have Used a GLP-1 Drug, Even If Unaffordable. JAMA. 2024;332(1):8. DOI:10.1001/jama.2024.10333</ref>. Originally developed as treatments for type 2 diabetes, medications such as Ozempic are now widely used for their ability to aid weight loss. As a GLP-1 receptor agonist (GLP-1 RA), semaglutide works by mimicking the effects of the GLP-1 hormone in the body. This action helps regulate the metabolic system, control appetite, and reduce calorie intake, leading to significant weight loss in many users. Semaglutide also slows gastric emptying, which prolongs the feeling of fullness after eating and further supports weight management. 


==Side effects==
==Side effects==
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Novikoff, Aaron et al. Why are we still in need for novel anti-obesity medications? The Lancet Regional Health – Europe, Volume 47, 101098
Novikoff, Aaron et al. Why are we still in need for novel anti-obesity medications? The Lancet Regional Health – Europe, Volume 47, 101098
[https://doi.org/10.1016/j.lanepe.2024.101098 DOI:10.1016/j.lanepe.2024.101098]</ref>.
[https://doi.org/10.1016/j.lanepe.2024.101098 DOI:10.1016/j.lanepe.2024.101098]</ref>.
==3D structures of semaglutide==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[7ki0]] - hSG + GLP-1 receptor + Gs proteins + nobody - human - Cryo EM<br />
[[7ki1]] - hTaspoglutide + GLP-1 receptor + Gs proteins + nobody - human - Cryo EM<br />
[[4zgm]] - hSG + GLP-1 receptor


==Student contributors==
==Student contributors==
Line 205: Line 236:
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
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