9l8o: Difference between revisions

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'''Unreleased structure'''


The entry 9l8o is ON HOLD
==Structure of SID-1 in complex with dsRNA (dodecameric form)==
 
<StructureSection load='9l8o' size='340' side='right'caption='[[9l8o]], [[Resolution|resolution]] 3.99&Aring;' scene=''>
Authors: Murakoshi, S., Kumazaki, K., Kusakizako, T., Nureki, O.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9l8o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L8O FirstGlance]. <br>
Description: Structure of SID-1 in complex with dsRNA (dodecameric form)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.99&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Kumazaki, K]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l8o OCA], [https://pdbe.org/9l8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l8o RCSB], [https://www.ebi.ac.uk/pdbsum/9l8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l8o ProSAT]</span></td></tr>
[[Category: Murakoshi, S]]
</table>
[[Category: Kusakizako, T]]
== Function ==
[[Category: Nureki, O]]
[https://www.uniprot.org/uniprot/SID1_CAEEL SID1_CAEEL] Plays a role in RNA-mediated gene silencing by acting cell-autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent (PubMed:26067272). Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa (PubMed:32908307).<ref>PMID:11834782</ref> <ref>PMID:12970568</ref> <ref>PMID:14738731</ref> <ref>PMID:17381285</ref> <ref>PMID:19155320</ref> <ref>PMID:19168628</ref> <ref>PMID:20512143</ref> <ref>PMID:21474576</ref> <ref>PMID:22178129</ref> <ref>PMID:22293577</ref> <ref>PMID:22902558</ref> <ref>PMID:26067272</ref> <ref>PMID:32908307</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Kumazaki K]]
[[Category: Kusakizako T]]
[[Category: Murakoshi S]]
[[Category: Nureki O]]
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