8z11

Cryo-EM structure of haptophyte photosystem I

spinqualitylabelsall models 8z11, resolution 2.74Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8z11 is a 10 chain structure with sequence from Isochrysis galbana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.74Å Ligands: A86, BCR, CLA, DD6, DGD, KC2, LHG, LMG, LMU, PQN, SQD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Haptophyta represents a major taxonomic group, with plastids derived from the primary plastids of red algae. Here, we elucidated the cryoelectron microscopy structure of the photosystem I-light-harvesting complex I (PSI-LHCI) supercomplex from the haptophyte Isochrysis galbana. The PSI core comprises 12 subunits, which have evolved differently from red algae and cryptophytes by losing the PsaO subunit while incorporating the PsaK subunit, which is absent in diatoms and dinoflagellates. The PSI core is encircled by 22 fucoxanthin-chlorophyll a/c-binding light-harvesting antenna proteins (iFCPIs) that form a trilayered antenna arrangement. Moreover, a pigment-binding subunit, L(iFP), which has not been identified in any other previously characterized PSI-LHCI supercomplexes, was determined in I. galbana PSI-iFCPI, presumably facilitating the interactions and energy transfer between peripheral iFCPIs and the PSI core. Calculation of excitation energy transfer rates by computational simulations revealed that the intricate pigment network formed within PSI-iFCPI ensures efficient transfer of excitation energy. Overall, our study provides a solid structural foundation for understanding the light-harvesting and energy transfer mechanisms in haptophyte PSI-iFCPI and provides insights into the evolution and structural variations of red-lineage PSI-LHCIs. Structural insights into the assembly and energy transfer of haptophyte photosystem I-light-harvesting supercomplex.,He FY, Zhao LS, Qu XX, Li K, Guo JP, Zhao F, Wang N, Qin BY, Chen XL, Gao J, Liu LN, Zhang YZ Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2413678121. doi: , 10.1073/pnas.2413678121. Epub 2024 Dec 6. PMID:39642204 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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