9mze: Difference between revisions

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New page: '''Unreleased structure''' The entry 9mze is ON HOLD Authors: Zhang, X., Belousoff, M.J., Wootten, D., Sexton, P.M. Description: Cryo-EM structure of GLP-1R-Gs complex with oxyntomodul...
 
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'''Unreleased structure'''


The entry 9mze is ON HOLD
==Cryo-EM structure of GLP-1R-Gs complex with oxyntomodulin==
 
<StructureSection load='9mze' size='340' side='right'caption='[[9mze]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
Authors: Zhang, X., Belousoff, M.J., Wootten, D., Sexton, P.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9mze]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MZE FirstGlance]. <br>
Description: Cryo-EM structure of GLP-1R-Gs complex with oxyntomodulin
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mze OCA], [https://pdbe.org/9mze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mze RCSB], [https://www.ebi.ac.uk/pdbsum/9mze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mze ProSAT]</span></td></tr>
[[Category: Sexton, P.M]]
</table>
[[Category: Belousoff, M.J]]
== Disease ==
[[Category: Wootten, D]]
[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
[[Category: Zhang, X]]
== Function ==
[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Belousoff MJ]]
[[Category: Sexton PM]]
[[Category: Wootten D]]
[[Category: Zhang X]]
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