9i6a: Difference between revisions
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New page: '''Unreleased structure''' The entry 9i6a is ON HOLD Authors: Eapen, R., Okoye, C., Stubbs, C., Schimpl, M., Tischer, T., Fisher, E.J., Zacharopoulou, M., Ferrer, F., Barford, D., Sprin... |
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==Crystal structure of human Cdc20 bound to synthetic D-box peptide D7== | |||
<StructureSection load='9i6a' size='340' side='right'caption='[[9i6a]], [[Resolution|resolution]] 1.92Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9i6a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I6A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.915Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JY:4-METHYL-L-LEUCINE'>0JY</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i6a OCA], [https://pdbe.org/9i6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i6a RCSB], [https://www.ebi.ac.uk/pdbsum/9i6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i6a ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/CDC20_HUMAN CDC20_HUMAN] Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.<ref>PMID:9811605</ref> <ref>PMID:9734353</ref> <ref>PMID:9637688</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Schimpl | [[Category: Large Structures]] | ||
[[Category: Spring | [[Category: Barford D]] | ||
[[Category: | [[Category: Eapen R]] | ||
[[Category: | [[Category: Ferrer F]] | ||
[[Category: Fisher EJ]] | |||
[[Category: Itzhaki LS]] | |||
[[Category: Lindon C]] | |||
[[Category: Okoye C]] | |||
[[Category: Phillips C]] | |||
[[Category: Schimpl M]] | |||
[[Category: Spring D]] | |||
[[Category: Stubbs C]] | |||
[[Category: Tischer T]] | |||
[[Category: Zacharopoulou M]] | |||
Latest revision as of 06:28, 12 February 2025
Crystal structure of human Cdc20 bound to synthetic D-box peptide D7
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