9lfw: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 9lfw is ON HOLD  until Paper Publication
==Crystal structure of mouse RIP3 kinase domain(R69H) complexed with LK01003==
 
<StructureSection load='9lfw' size='340' side='right'caption='[[9lfw]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
Authors: Xie, H., Su, H.X., Li, M.J., Xu, Y.C.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9lfw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LFW FirstGlance]. <br>
Description: Crystal structure of mouse RIP3 kinase domain(R69H) complexed with LK01003
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D97:2-cyclopentyl-~{N}-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine'>A1D97</scene></td></tr>
[[Category: Li, M.J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lfw OCA], [https://pdbe.org/9lfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lfw RCSB], [https://www.ebi.ac.uk/pdbsum/9lfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lfw ProSAT]</span></td></tr>
[[Category: Xu, Y.C]]
</table>
[[Category: Su, H.X]]
== Function ==
[[Category: Xie, H]]
[https://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Li MJ]]
[[Category: Su HX]]
[[Category: Xie H]]
[[Category: Xu YC]]
Retrieved from "https://proteopedia.org/9lfw"