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[[Image:1v1o.gif|left|200px]]
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{{STRUCTURE_1v1o|  PDB=1v1o  |  SCENE=  }}
'''STAPHYLOCOCCAL SUPERANTIGEN-LIKE PROTEIN 7'''


==staphylococcal superantigen-like protein 7==
<StructureSection load='1v1o' size='340' side='right'caption='[[1v1o]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1v1o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V1O FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1o OCA], [https://pdbe.org/1v1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v1o RCSB], [https://www.ebi.ac.uk/pdbsum/1v1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v1o ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9ZFS5_STAAU Q9ZFS5_STAAU]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/1v1o_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v1o ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The staphylococcal superantigen-like proteins (SSLs) are a family of polymorphic paralogs encoded in the Staphylococcus aureus genome whose function is unknown. The crystal structure of SSL7 was determined and compared to that of SSL5 and that of a classical superantigen, streptococcal pyrogenic exotoxin. Although the overall architecture of the superantigen family is retained in both SSL7 and SSL5, there are significant differences in the structures which suggest that the characteristic major histocompatibility complex binding site of superantigens has been lost. To complement these data, the abilities of SSL7 and a closely related paralog, SSL9, to interact with cells of the immune system were investigated. In populations of human white blood cells, both SSLs interacted selectively with monocytes via specific saturable but separate binding sites, which led to rapid uptake of the SSLs. In addition, SSLs were rapidly taken up by dendritic cells, but not by macrophages, into the same endosomal compartment as dextran. The ability of these secreted proteins to target antigen-presenting cells may enhance a misplaced antibody response against the proteins, which may facilitate bacterial colonization rather than contribute to host protection. Like classical superantigens, therefore, SSLs may distract the host's immune system, but they may do so via entirely different molecular mechanisms.


==Overview==
Structural relationships and cellular tropism of staphylococcal superantigen-like proteins.,Al-Shangiti AM, Naylor CE, Nair SP, Briggs DC, Henderson B, Chain BM Infect Immun. 2004 Jul;72(7):4261-70. PMID:15213171<ref>PMID:15213171</ref>
The staphylococcal superantigen-like proteins (SSLs) are a family of polymorphic paralogs encoded in the Staphylococcus aureus genome whose function is unknown. The crystal structure of SSL7 was determined and compared to that of SSL5 and that of a classical superantigen, streptococcal pyrogenic exotoxin. Although the overall architecture of the superantigen family is retained in both SSL7 and SSL5, there are significant differences in the structures which suggest that the characteristic major histocompatibility complex binding site of superantigens has been lost. To complement these data, the abilities of SSL7 and a closely related paralog, SSL9, to interact with cells of the immune system were investigated. In populations of human white blood cells, both SSLs interacted selectively with monocytes via specific saturable but separate binding sites, which led to rapid uptake of the SSLs. In addition, SSLs were rapidly taken up by dendritic cells, but not by macrophages, into the same endosomal compartment as dextran. The ability of these secreted proteins to target antigen-presenting cells may enhance a misplaced antibody response against the proteins, which may facilitate bacterial colonization rather than contribute to host protection. Like classical superantigens, therefore, SSLs may distract the host's immune system, but they may do so via entirely different molecular mechanisms.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1V1O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1O OCA].
</div>
<div class="pdbe-citations 1v1o" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Structural relationships and cellular tropism of staphylococcal superantigen-like proteins., Al-Shangiti AM, Naylor CE, Nair SP, Briggs DC, Henderson B, Chain BM, Infect Immun. 2004 Jul;72(7):4261-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15213171 15213171]
*[[Exotoxin 3D structures|Exotoxin 3D structures]]
[[Category: Single protein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Al-Shangiti, A M.]]
[[Category: Al-Shangiti AM]]
[[Category: Briggs, D C.]]
[[Category: Briggs DC]]
[[Category: Nair, S P.]]
[[Category: Nair SP]]
[[Category: Naylor, C E.]]
[[Category: Naylor CE]]
[[Category: Antigen presenting cell]]
[[Category: Secreted protein]]
[[Category: Set1]]
[[Category: Staphylococcal exotoxin 1]]
[[Category: Virulence factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:58:28 2008''

Latest revision as of 13:07, 13 December 2023

staphylococcal superantigen-like protein 7

1v1o, resolution 2.75Å

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