9q8y: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9q8y is ~~ON HOLD~~

==Structure of RNF38 RING with linchpin mutant R454Y in complex with Ubch5B-Ub==

~~Authors~~: ~~Gabrielsen~~, M., ~~Buetow~~, L., ~~Huang~~, D.T.

== Structural highlights ==

<table><tr><td colspan='2'>[[9q8y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Q8Y OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9Q8Y FirstGlance].

~~Description~~: ~~Structure~~ of ~~RNF38 RING with linchpin mutant R454Y~~ in ~~complex with Ubch5B~~-Ub

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Gabrielsen, M~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9q8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9q8y OCA], [https://pdbe.org/9q8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9q8y RCSB], [https://www.ebi.ac.uk/pdbsum/9q8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9q8y ProSAT]</td></tr>

[[Category: ~~Huang, D.T~~]]

</table>

[[Category: ~~Buetow, L~~]]

== Function ==

[https://www.uniprot.org/uniprot/UB2D2_HUMAN UB2D2_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.<ref>PMID:10329681</ref> <ref>PMID:15280377</ref> <ref>PMID:18042044</ref> <ref>PMID:18703417</ref> <ref>PMID:18359941</ref> <ref>PMID:19854139</ref> <ref>PMID:20403326</ref> <ref>PMID:20061386</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Buetow L]]

[[Category: Gabrielsen M]]

[[Category: Huang DT]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9q8y is ON HOLD
+==Structure of RNF38 RING with linchpin mutant R454Y in complex with Ubch5B-Ub==
+<StructureSection load='9q8y' size='340' side='right'caption='[[9q8y]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
-Authors: Gabrielsen, M., Buetow, L., Huang, D.T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9q8y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Q8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Q8Y FirstGlance]. <br>
-Description: Structure of RNF38 RING with linchpin mutant R454Y in complex with Ubch5B-Ub
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Gabrielsen, M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9q8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9q8y OCA], [https://pdbe.org/9q8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9q8y RCSB], [https://www.ebi.ac.uk/pdbsum/9q8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9q8y ProSAT]</span></td></tr>
-[[Category: Huang, D.T]]
+</table>
-[[Category: Buetow, L]]
+== Function ==
+[https://www.uniprot.org/uniprot/UB2D2_HUMAN UB2D2_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.<ref>PMID:10329681</ref> <ref>PMID:15280377</ref> <ref>PMID:18042044</ref> <ref>PMID:18703417</ref> <ref>PMID:18359941</ref> <ref>PMID:19854139</ref> <ref>PMID:20403326</ref> <ref>PMID:20061386</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Buetow L]]
+[[Category: Gabrielsen M]]
+[[Category: Huang DT]]