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[[Image:1v75.gif|left|200px]]
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{{STRUCTURE_1v75|  PDB=1v75  |  SCENE=  }}
'''Crystal structure of hemoglobin D from the Aldabra giant tortoise (Geochelone gigantea) at 2.0 A resolution'''


==Crystal structure of hemoglobin D from the Aldabra giant tortoise (Geochelone gigantea) at 2.0 A resolution==
<StructureSection load='1v75' size='340' side='right'caption='[[1v75]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1v75]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aldabrachelys_gigantea Aldabrachelys gigantea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V75 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v75 OCA], [https://pdbe.org/1v75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v75 RCSB], [https://www.ebi.ac.uk/pdbsum/1v75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v75 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HBAD_ALDGI HBAD_ALDGI] Involved in oxygen transport from the lung to the various peripheral tissues.[UniProtKB:P07417]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v7/1v75_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v75 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Hemoglobin D (Hb D) from the Aldabra giant tortoise, Geochelone gigantea, was crystallized by the hanging drop vapor diffusion technique with a precipitant solution containing 10% polyethylene glycol 3350 and 50 mM HEPES-Na, pH 7.5. The Hb D crystals of G. gigantea, which diffract to at least a 2.0 A resolution, belong to the monoclinic space group C2 with unit cell dimensions of a = 112.1 A, b = 62.4 A, c = 54.0 A, and beta = 110.3 degrees. One alphabeta dimer molecule of Hb D existed in an asymmetric unit, with a calculated value of Vm of 2.77 A(3)Da(-1).


==Overview==
Crystallization and preliminary X-ray diffraction study of hemoglobin D from the Aldabra giant tortoise, Geochelone gigantea.,Kuwada T, Hasegawa T, Satoh I, Ishikawa K, Shishikura F Protein Pept Lett. 2003 Aug;10(4):422-5. PMID:14529497<ref>PMID:14529497</ref>
Hemoglobin D (Hb D) from the Aldabra giant tortoise, Geochelone gigantea, was crystallized by the hanging drop vapor diffusion technique with a precipitant solution containing 10% polyethylene glycol 3350 and 50 mM HEPES-Na, pH 7.5. The Hb D crystals of G. gigantea, which diffract to at least a 2.0 A resolution, belong to the monoclinic space group C2 with unit cell dimensions of a = 112.1 A, b = 62.4 A, c = 54.0 A, and beta = 110.3 degrees. One alphabeta dimer molecule of Hb D existed in an asymmetric unit, with a calculated value of Vm of 2.77 A(3)Da(-1).


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1V75 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Dipsochelys_dussumieri Dipsochelys dussumieri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V75 OCA].
</div>
<div class="pdbe-citations 1v75" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Crystallization and preliminary X-ray diffraction study of hemoglobin D from the Aldabra giant tortoise, Geochelone gigantea., Kuwada T, Hasegawa T, Satoh I, Ishikawa K, Shishikura F, Protein Pept Lett. 2003 Aug;10(4):422-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14529497 14529497]
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
[[Category: Dipsochelys dussumieri]]
== References ==
[[Category: Protein complex]]
<references/>
[[Category: Hasegawa, T.]]
__TOC__
[[Category: Ishikawa, K.]]
</StructureSection>
[[Category: Kuwada, T.]]
[[Category: Aldabrachelys gigantea]]
[[Category: Satoh, I.]]
[[Category: Large Structures]]
[[Category: Shishikura, F.]]
[[Category: Hasegawa T]]
[[Category: Geochelone gigantea]]
[[Category: Ishikawa K]]
[[Category: Hemoglobin d]]
[[Category: Kuwada T]]
[[Category: Reptilia]]
[[Category: Satoh I]]
[[Category: The aldabra giant tortoise]]
[[Category: Shishikura F]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:10:17 2008''

Latest revision as of 07:19, 13 August 2026

Crystal structure of hemoglobin D from the Aldabra giant tortoise (Geochelone gigantea) at 2.0 A resolution

1v75, resolution 2.02Å

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