9k3p: Difference between revisions

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'''Unreleased structure'''


The entry 9k3p is ON HOLD  until Paper Publication
==Cryo-EM structure of the unliganded human melanocortin receptor 1 (MC1R)-Gs complex==
 
<StructureSection load='9k3p' size='340' side='right'caption='[[9k3p]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
Authors: Feng, W.B., Zhou, Q.T., Zheng, C., Yang, D.H., Wang, M.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9k3p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9K3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9K3P FirstGlance]. <br>
Description: Cryo-EM structure of the unliganded human melanocortin receptor 1 (MC1R)-Gs complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.98&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9k3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9k3p OCA], [https://pdbe.org/9k3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9k3p RCSB], [https://www.ebi.ac.uk/pdbsum/9k3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9k3p ProSAT]</span></td></tr>
[[Category: Zheng, C]]
</table>
[[Category: Zhou, Q.T]]
== Disease ==
[[Category: Feng, W.B]]
[https://www.uniprot.org/uniprot/MSHR_HUMAN MSHR_HUMAN] Familial melanoma;Oculocutaneous albinism type 2. Disease susceptibility is associated with variants affecting the gene represented in this entry.
[[Category: Yang, D.H]]
== Function ==
[[Category: Wang, M.W]]
[https://www.uniprot.org/uniprot/MSHR_HUMAN MSHR_HUMAN] Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:11442765, PubMed:11707265, PubMed:1325670, PubMed:1516719, PubMed:8463333). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11707265, PubMed:1325670, PubMed:16463023, PubMed:19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585).<ref>PMID:11442765</ref> <ref>PMID:11707265</ref> <ref>PMID:1325670</ref> <ref>PMID:1516719</ref> <ref>PMID:16463023</ref> <ref>PMID:19737927</ref> <ref>PMID:31097585</ref> <ref>PMID:8463333</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Feng WB]]
[[Category: Wang MW]]
[[Category: Yang DH]]
[[Category: Zheng C]]
[[Category: Zhou QT]]
Retrieved from "https://proteopedia.org/9k3p"