9m76: Difference between revisions
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New page: '''Unreleased structure''' The entry 9m76 is ON HOLD Authors: Description: Category: Unreleased Structures |
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==UHRF1 bound to a mononucleosome in its pre-active state, with the RING domain bound to the SRA domain.== | |||
<StructureSection load='9m76' size='340' side='right'caption='[[9m76]], [[Resolution|resolution]] 4.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9m76]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M76 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m76 OCA], [https://pdbe.org/9m76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m76 RCSB], [https://www.ebi.ac.uk/pdbsum/9m76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m76 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Baradaran R]] | |||
[[Category: Fischle W]] | |||
[[Category: Naschberger A]] | |||
[[Category: Sayed A]] | |||
Latest revision as of 09:00, 11 March 2026
UHRF1 bound to a mononucleosome in its pre-active state, with the RING domain bound to the SRA domain.
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