9nr8: Difference between revisions
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New page: '''Unreleased structure''' The entry 9nr8 is ON HOLD Authors: Fang, C.F., Gouaux, E. Description: The structure of GluA1/A4 LBD-TMD in Noelin-AMPAR complex [[Category: Unreleased Struc... |
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The | ==The structure of cerebellar GluA1/A4 ATD== | ||
<StructureSection load='9nr8' size='340' side='right'caption='[[9nr8]], [[Resolution|resolution]] 3.53Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9nr8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NR8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.53Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
[[Category: Fang | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nr8 OCA], [https://pdbe.org/9nr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nr8 RCSB], [https://www.ebi.ac.uk/pdbsum/9nr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nr8 ProSAT]</span></td></tr> | ||
[[Category: Gouaux | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GRIA1_RAT GRIA1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:16793768</ref> <ref>PMID:19265014</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Fang CF]] | |||
[[Category: Gouaux E]] | |||
Latest revision as of 05:36, 3 July 2025
The structure of cerebellar GluA1/A4 ATD
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