9mcb: Difference between revisions
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New page: '''Unreleased structure''' The entry 9mcb is ON HOLD Authors: Chen, P.-T., Wu, K.-P. Description: Cryo-EM structure of Human UBA1-UBE2O-Ub -Recruitment state 1 [[Category: Unreleased S... |
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==Cryo-EM structure of Human UBA1-UBE2O-Ub -Recruitment state 1== | |||
<StructureSection load='9mcb' size='340' side='right'caption='[[9mcb]], [[Resolution|resolution]] 3.42Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9mcb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MCB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.42Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mcb OCA], [https://pdbe.org/9mcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mcb RCSB], [https://www.ebi.ac.uk/pdbsum/9mcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mcb ProSAT]</span></td></tr> | ||
[[Category: Chen | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/UBA1_HUMAN UBA1_HUMAN] X-linked distal arthrogryposis multiplex congenita. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UBA1_HUMAN UBA1_HUMAN] Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.<ref>PMID:22456334</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen P-T]] | |||
[[Category: Wu K-P]] | |||
Latest revision as of 07:47, 25 March 2026
Cryo-EM structure of Human UBA1-UBE2O-Ub -Recruitment state 1
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