9hju: Difference between revisions
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==Structure of 2x Zincore (SEPHS1:QRICH1) binding to ZFP91 on DNA== | |||
<StructureSection load='9hju' size='340' side='right'caption='[[9hju]], [[Resolution|resolution]] 3.16Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9hju]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HJU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.16Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hju OCA], [https://pdbe.org/9hju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hju RCSB], [https://www.ebi.ac.uk/pdbsum/9hju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hju ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ZFP91_HUMAN ZFP91_HUMAN] Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.<ref>PMID:12738986</ref> <ref>PMID:20682767</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Borza R]] | |||
[[Category: Perrakis A]] | |||
Latest revision as of 16:20, 9 July 2025
Structure of 2x Zincore (SEPHS1:QRICH1) binding to ZFP91 on DNA
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