1yyb: Difference between revisions
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== | ==Solution structure of 1-26 fragment of human programmed cell death 5 protein== | ||
PDCD5-(1-26) is a N-terminal 26-residue fragment of human PDCD5 | <StructureSection load='1yyb' size='340' side='right'caption='[[1yyb]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1yyb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YYB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yyb OCA], [https://pdbe.org/1yyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yyb RCSB], [https://www.ebi.ac.uk/pdbsum/1yyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yyb ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDCD5_HUMAN PDCD5_HUMAN] May function in the process of apoptosis. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
PDCD5-(1-26) is a N-terminal 26-residue fragment of human PDCD5 (programmed cell death 5) protein. PDCD5 is an important novel protein that regulates both apoptotic and non-apoptotic programmed cell death. The conformation of PDCD5 protein is a stable helical core consisting of a triple-helix bundle and two dissociated terminal regions. The N-terminal region is ordered and contains abundant secondary structure. Overexpression and purification of the N-terminal 26-residure fragment, PDCD5-(1-26), was performed in this study to better understand its tertiary structure. The spectroscopic studies using CD and hetero- and homo-nuclear NMR methods determine a stable alpha-helix formed by Asp3-Ala19 of PDCD5-(1-26). The N-terminal residues Asp3-Ala19 of PDCD5 were then affirmed to have the capacity to form a stable alpha-helix independently of the core of the protein. Analysis of the helical peptide of PDCD5-(1-26) indicates that the surface of this well-formed alpha-helix has a unique electrostatic potential character. This may provide an environment for the N-terminal alpha-helix of PDCD5 to serve as an independent functional entity of the protein. The apoptosis activity assay shows that the deletion of the N-terminal alpha-helix of PDCD5 significantly attenuates the apoptosis-promoting effects on HL-60 cells induced by serum withdrawal. | |||
The N-terminal 26-residue fragment of human programmed cell death 5 protein can form a stable alpha-helix having unique electrostatic potential character.,Liu D, Yao H, Chen Y, Feng Y, Chen Y, Wang J Biochem J. 2005 Nov 15;392(Pt 1):47-54. PMID:16083422<ref>PMID:16083422</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
<div class="pdbe-citations 1yyb" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Cell death protein 3D structures|Cell death protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Feng | [[Category: Feng YG]] | ||
[[Category: Liu | [[Category: Liu DS]] | ||
[[Category: Wang | [[Category: Wang JF]] | ||
[[Category: Yao | [[Category: Yao HW]] | ||
Latest revision as of 09:31, 6 December 2023
Solution structure of 1-26 fragment of human programmed cell death 5 protein
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