9o1i: Difference between revisions
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New page: '''Unreleased structure''' The entry 9o1i is ON HOLD Authors: Feng, Z., Accardi, A. Description: TMEM16F in liposomes in the absence of Ca2+ (contracted state) [[Category: Unreleased S... |
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==TMEM16F in liposomes in the absence of Ca2+ (contracted state)== | |||
<StructureSection load='9o1i' size='340' side='right'caption='[[9o1i]], [[Resolution|resolution]] 2.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9o1i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O1I FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.49Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o1i OCA], [https://pdbe.org/9o1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o1i RCSB], [https://www.ebi.ac.uk/pdbsum/9o1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o1i ProSAT]</span></td></tr> | ||
[[Category: Accardi | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ANO6_MOUSE ANO6_MOUSE] Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.<ref>PMID:21107324</ref> <ref>PMID:21908539</ref> <ref>PMID:22936354</ref> <ref>PMID:23021219</ref> <ref>PMID:23532839</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Accardi A]] | |||
[[Category: Feng Z]] | |||
Latest revision as of 09:24, 15 April 2026
TMEM16F in liposomes in the absence of Ca2+ (contracted state)
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