9o1p: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
New page: '''Unreleased structure''' The entry 9o1p is ON HOLD Authors: Feng, Z., Accardi, A. Description: TMEM16F D409G mutant in liposomes in the presence of Ca2+ (closed state) [[Category: Un...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 9o1p is ON HOLD
==TMEM16F D409G mutant in liposomes in the presence of Ca2+ (closed state)==
 
<StructureSection load='9o1p' size='340' side='right'caption='[[9o1p]], [[Resolution|resolution]] 3.48&Aring;' scene=''>
Authors: Feng, Z., Accardi, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9o1p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O1P FirstGlance]. <br>
Description: TMEM16F D409G mutant in liposomes in the presence of Ca2+ (closed state)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.48&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
[[Category: Feng, Z]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o1p OCA], [https://pdbe.org/9o1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o1p RCSB], [https://www.ebi.ac.uk/pdbsum/9o1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o1p ProSAT]</span></td></tr>
[[Category: Accardi, A]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANO6_MOUSE ANO6_MOUSE] Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.<ref>PMID:21107324</ref> <ref>PMID:21908539</ref> <ref>PMID:22936354</ref> <ref>PMID:23021219</ref> <ref>PMID:23532839</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Accardi A]]
[[Category: Feng Z]]
Retrieved from "https://proteopedia.org/9o1p"