9qu4: Difference between revisions
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==Cryo-EM structure of the inward-open choline-bound state of choline/ethanolamine transporter FLVCR2== | |||
<StructureSection load='9qu4' size='340' side='right'caption='[[9qu4]], [[Resolution|resolution]] 3.39Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9qu4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QU4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.39Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHT:CHOLINE+ION'>CHT</scene></td></tr> | ||
[[Category: Driller | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qu4 OCA], [https://pdbe.org/9qu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qu4 RCSB], [https://www.ebi.ac.uk/pdbsum/9qu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qu4 ProSAT]</span></td></tr> | ||
[[Category: Nel | </table> | ||
[[Category: Pedersen | == Disease == | ||
[https://www.uniprot.org/uniprot/FLVC2_HUMAN FLVC2_HUMAN] Fowler vasculopathy. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SPA_STAA8 SPA_STAA8] [https://www.uniprot.org/uniprot/FLVC2_HUMAN FLVC2_HUMAN] Putative heme b importer/sensor involved in heme homeostasis in response to the metabolic state of the cell and to diet. May act as a sensor of cytosolic and/or mitochondrial heme levels to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis. At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis. Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis. Alternatively, in coordination with ATP2A2 may mediate calcium transport and signaling in response to heme.<ref>PMID:20823265</ref> <ref>PMID:32973183</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Driller JH]] | |||
[[Category: Nel L]] | |||
[[Category: Pedersen BP]] | |||
Latest revision as of 05:36, 27 May 2026
Cryo-EM structure of the inward-open choline-bound state of choline/ethanolamine transporter FLVCR2
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