9quk: Difference between revisions
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New page: '''Unreleased structure''' The entry 9quk is ON HOLD Authors: Hofer, G., Wang, L., Pacoste, L., Hager, P., Fonjallaz, A., Scaletti Hutchinson, E., Stenmark, P., Di Palma, M., Williams, ... |
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==Structure of human MTH1 in complex with 8DG by MicroED using low electron fluence== | |||
<StructureSection load='9quk' size='340' side='right'caption='[[9quk]], [[Resolution|resolution]] 2.86Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9quk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QUK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 2.86Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8DG:8-OXO-2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>8DG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9quk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9quk OCA], [https://pdbe.org/9quk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9quk RCSB], [https://www.ebi.ac.uk/pdbsum/9quk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9quk ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref> | ||
[[Category: Pacoste | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Di Palma M]] | ||
[[Category: | [[Category: Fonjallaz A]] | ||
[[Category: | [[Category: Hager P]] | ||
[[Category: Hofer G]] | |||
[[Category: Pacoste L]] | |||
[[Category: Scaletti Hutchinson E]] | |||
[[Category: Steiner R]] | |||
[[Category: Stenmark P]] | |||
[[Category: Wang L]] | |||
[[Category: Williams L]] | |||
[[Category: Worral J]] | |||
[[Category: Xu H]] | |||
[[Category: Zou X]] | |||
Latest revision as of 06:30, 22 April 2026
Structure of human MTH1 in complex with 8DG by MicroED using low electron fluence
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