9o7m: Difference between revisions

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New page: '''Unreleased structure''' The entry 9o7m is ON HOLD Authors: Guzzo, C.R., Araujo, G.G., Merighi, D.G.S. Description: Cryo-EM Structure of YfdQ Reveals a Widespread Novel Family of Bac...
 
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'''Unreleased structure'''


The entry 9o7m is ON HOLD
==Cryo-EM Structure of YfdQ Reveals a Widespread Novel Family of Bacteriophage-Associated Proteins with Shell-Like Assemblies==
<StructureSection load='9o7m' size='340' side='right'caption='[[9o7m]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9o7m]] is a 36 chain structure with sequence from [https://en.wikipedia.org/wiki/Caudoviricetes Caudoviricetes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O7M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o7m OCA], [https://pdbe.org/9o7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o7m RCSB], [https://www.ebi.ac.uk/pdbsum/9o7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o7m ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bacteriophages are key players in microbial ecosystems with strong biotechnological potential, yet many phage-encoded proteins remain uncharacterized. We present the structure of the YfdQ complex from the Xanthomonas citri PhiXacm4-11 phage, a conserved DUF2303 protein encoded by double-stranded DNA bacteriophages of the Caudoviricetes class. Using cryo-electron microscopy, we report that native YfdQ assembles into a shell-like structure with D18 symmetry forming a approximately 1.1 MegaDalton complex, a hollow interior and a unique equatorial beta strand stitching oligomerization interface that holds together the two hemispheres. YfdQ homologs are widely distributed among phages infecting diverse bacterial hosts, suggesting a conserved biological role. YfdQ are found in prophages and cryptic phages. Our results suggest that heterologous expression of YfdQ in X. citri and in Escherichia coli allows the obtention of structurally heterogeneous YfdQ complexes, suggesting that its proper assembly into the shell-like structure may depend on still unidentified viral factors.


Authors: Guzzo, C.R., Araujo, G.G., Merighi, D.G.S.
Cryo-EM structure of YfdQ reveals a widespread family of bacteriophage-associated proteins with shell-like assemblies.,Merighi DGS, Pompeu GC, Araujo GG, Silva de Souza A, Sgro GG, Farah CS, Guzzo CR Structure. 2026 Jun 17:S0969-2126(26)00155-3. doi: 10.1016/j.str.2026.05.009. PMID:42309054<ref>PMID:42309054</ref>


Description: Cryo-EM Structure of YfdQ Reveals a Widespread Novel Family of Bacteriophage-Associated Proteins with Shell-Like Assemblies
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Guzzo, C.R]]
<div class="pdbe-citations 9o7m" style="background-color:#fffaf0;"></div>
[[Category: Araujo, G.G]]
== References ==
[[Category: Merighi, D.G.S]]
<references/>
__TOC__
</StructureSection>
[[Category: Caudoviricetes]]
[[Category: Large Structures]]
[[Category: Araujo GG]]
[[Category: Guzzo CR]]
[[Category: Merighi DGS]]
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