1z32: Difference between revisions

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New page: left|200px<br /> <applet load="1z32" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z32, resolution 1.60Å" /> '''Structure-function ...
 
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[[Image:1z32.gif|left|200px]]<br />
<applet load="1z32" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1z32, resolution 1.60&Aring;" />
'''Structure-function relationships in human salivary alpha-amylase: Role of aromatic residues'''<br />


==About this Structure==
==Structure-function relationships in human salivary alpha-amylase: Role of aromatic residues==
1Z32 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Z32 OCA].  
<StructureSection load='1z32' size='340' side='right'caption='[[1z32]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
[[Category: Alpha-amylase]]
== Structural highlights ==
<table><tr><td colspan='2'>[[1z32]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z32 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGL:4,6-DIDEOXY-4-AMINO-ALPHA-D-GLUCOSE'>AGL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=HMC:5-HYDROXYMETHYL-CHONDURITOL'>HMC</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z32 OCA], [https://pdbe.org/1z32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z32 RCSB], [https://www.ebi.ac.uk/pdbsum/1z32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z32 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMY1A_HUMAN AMY1A_HUMAN] Calcium-binding enzyme that initiates starch digestion in the oral cavity (PubMed:12527308). Catalyzes the hydrolysis of internal (1->4)-alpha-D-glucosidic bonds, yielding a mixture of maltose, isomaltose, small amounts of glucose as well as small linear and branched oligosaccharides called dextrins (PubMed:12527308).<ref>PMID:12527308</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z32_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z32 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Amylase 3D structures|Amylase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Gyemant, G.]]
[[Category: Gyemant G]]
[[Category: Kandra, L.]]
[[Category: Kandra L]]
[[Category: Mishra, P.J.]]
[[Category: Mishra PJ]]
[[Category: Ragunath, C.]]
[[Category: Ragunath C]]
[[Category: Ramasubbu, N.]]
[[Category: Ramasubbu N]]
[[Category: Sundar, K.]]
[[Category: Sundar K]]
[[Category: CA]]
[[Category: CL]]
[[Category: tim barrel]]
 
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Retrieved from "https://proteopedia.org/1z32"