1z4r: Difference between revisions

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New page: left|200px<br /> <applet load="1z4r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z4r, resolution 1.74Å" /> '''Human GCN5 Acetyltr...
 
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[[Image:1z4r.gif|left|200px]]<br />
<applet load="1z4r" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1z4r, resolution 1.74&Aring;" />
'''Human GCN5 Acetyltransferase'''<br />


==About this Structure==
==Human GCN5 Acetyltransferase==
1Z4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ACO as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Z4R OCA].  
<StructureSection load='1z4r' size='340' side='right'caption='[[1z4r]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
[[Category: Histone acetyltransferase]]
== Structural highlights ==
<table><tr><td colspan='2'>[[1z4r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z4R FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4r OCA], [https://pdbe.org/1z4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4r RCSB], [https://www.ebi.ac.uk/pdbsum/1z4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4r ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KAT2A_HUMAN KAT2A_HUMAN] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:17301242</ref> <ref>PMID:19103755</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4r_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z4r ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Antoshenko, T.]]
[[Category: Antoshenko T]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Bernstein, G.]]
[[Category: Bernstein G]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Dong, A.]]
[[Category: Dong A]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Loppnau, P.]]
[[Category: Loppnau P]]
[[Category: Plotnikov, A.]]
[[Category: Plotnikov A]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Schuetz A]]
[[Category: Schuetz, A.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Wu H]]
[[Category: Wu, H.]]
[[Category: ACO]]
[[Category: acetyltransferase]]
[[Category: gcn5]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
 
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Retrieved from "https://proteopedia.org/1z4r"