9ocj: Difference between revisions

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'''Unreleased structure'''


The entry 9ocj is ON HOLD
==Transporter associated with antigen processing (TAP) bound to the viral protein CPXV012 in the outward-facing open state==
 
<StructureSection load='9ocj' size='340' side='right'caption='[[9ocj]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
Authors: Lee, J., Manon, V., Chen, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9ocj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OCJ FirstGlance]. <br>
Description: Transporter associated with antigen processing (TAP) bound to the viral protein CPXV012 in the outward-facing open state
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Lee, J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ocj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ocj OCA], [https://pdbe.org/9ocj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ocj RCSB], [https://www.ebi.ac.uk/pdbsum/9ocj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ocj ProSAT]</span></td></tr>
[[Category: Chen, J]]
</table>
[[Category: Manon, V]]
== Disease ==
[https://www.uniprot.org/uniprot/TAP2_HUMAN TAP2_HUMAN] Immunodeficiency by defective expression of HLA class 1. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TAP2_HUMAN TAP2_HUMAN] Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
__TOC__
</StructureSection>
[[Category: Cowpox virus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen J]]
[[Category: Lee J]]
[[Category: Manon V]]
Retrieved from "https://proteopedia.org/9ocj"