9umf: Difference between revisions
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New page: '''Unreleased structure''' The entry 9umf is ON HOLD Authors: Yan, M., Zhang, H. Description: Human poly ADP-ribose polymerase(PARP-1 )zinc finger 1 bound to 17bp DNA [[Category: Unrel... |
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==Human poly ADP-ribose polymerase(PARP-1 )zinc finger 1 bound to 17bp DNA== | |||
<StructureSection load='9umf' size='340' side='right'caption='[[9umf]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9umf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UMF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: Yan | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9umf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9umf OCA], [https://pdbe.org/9umf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9umf RCSB], [https://www.ebi.ac.uk/pdbsum/9umf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9umf ProSAT]</span></td></tr> | ||
[[Category: Zhang | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Yan M]] | |||
[[Category: Zhang H]] | |||
Latest revision as of 08:23, 29 April 2026
Human poly ADP-ribose polymerase(PARP-1 )zinc finger 1 bound to 17bp DNA
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