9uo7: Difference between revisions
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New page: '''Unreleased structure''' The entry 9uo7 is ON HOLD Authors: Description: Category: Unreleased Structures |
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==L. donovani Cell cycle associated protein MOB1== | |||
<StructureSection load='9uo7' size='340' side='right'caption='[[9uo7]], [[Resolution|resolution]] 1.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9uo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UO7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uo7 OCA], [https://pdbe.org/9uo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uo7 RCSB], [https://www.ebi.ac.uk/pdbsum/9uo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uo7 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Monopolar spindle One Binder (MOB1) proteins, recently identified as tumor suppressors, are essential regulators of the cell cycle, ensuring proper chromosome segregation and ploidy maintenance during mitotic exit and transition to cytokinesis. MOB1 also works as an adaptor protein for upstream Mammalian sterile 20-like kinase (MST1/2) and downstream Large Tumor Suppressor (LATS1) kinases in the Hippo pathway. Evolutionarily conserved, MOB proteins show differences in their N-terminal region and phosphorylation sites. Here, we describe the crystal structure of Leishmania donovani MOB1 (LdMOB1) elucidated at 1.3 A. LdMOB1 adopts a compact, globular conformation, with its core architecture similar to its homologs with a conformational variability in its N- and C-termini. Phosphorylation assays of native and T14A mutant LdMOB1 revealed that LdMOB1 undergoes reversible phosphorylation. Our results suggest that the potential phosphorylation sites are Ser 167 and Thr 170, distinct from the Thr 12 and Thr 35 in human MOB1. Computational protein-protein interaction studies confirm the plausibility of the identified phosphorylation sites. | |||
Crystal structure of the cell-cycle regulatory monopolar spindle one binder (LdMOB1) protein: Identification of potential distinct phosphorylation sites.,Saw S, Parihar PS, Sahasrabuddhe AA, Trivedi AK, Pratap JV Int J Biol Macromol. 2026 Feb;344(Pt 1):150395. doi: , 10.1016/j.ijbiomac.2026.150395. Epub 2026 Jan 21. PMID:41577278<ref>PMID:41577278</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 9uo7" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Leishmania donovani]] | |||
[[Category: Parihar PS]] | |||
[[Category: Pratap JV]] | |||
[[Category: Saw S]] | |||
