9upg: Difference between revisions
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New page: '''Unreleased structure''' The entry 9upg is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Cryo-EM structure of human olfactory CNGA2/A4/B1 in CaM-bound closed state== | |||
<StructureSection load='9upg' size='340' side='right'caption='[[9upg]], [[Resolution|resolution]] 2.87Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9upg]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UPG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.87Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9upg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9upg OCA], [https://pdbe.org/9upg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9upg RCSB], [https://www.ebi.ac.uk/pdbsum/9upg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9upg ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/CNGA2_HUMAN CNGA2_HUMAN] Isolated congenital anosmia. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CNGA2_HUMAN CNGA2_HUMAN] Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations.[UniProtKB:Q00195] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Jiang Y]] | |||
[[Category: Xue J]] | |||
