Intrinsically Disordered Protein: Difference between revisions
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=== Prediction Servers === | === Prediction Servers === | ||
The sequence display for protein structure entries at [https://rcsb.org RCSB.org] includes a [http://firstglance.jmol.org/disopred.htm line graphically representing disorder predicted by IUPred] (see below). Enter the [[PDB ID]] into the search slot at the top of the page at [https://rcsb.org RCSB.org], then click on the ''Sequence'' tab. | |||
The quality of predictions by various algorithms have been evaluated beginning in CASP5 (2002). The assessment of disorder predictions for CASP8 (2008) has been published<ref>PMID: 19774619</ref>. | The quality of predictions by various algorithms have been evaluated beginning in CASP5 (2002). The assessment of disorder predictions for CASP8 (2008) has been published<ref>PMID: 19774619</ref>. | ||
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Meta-servers gather the predictions from other servers into a single report. | Meta-servers gather the predictions from other servers into a single report. | ||
* [http://mobidb.bio.unipd.it/ MobiDB]. The ''Structure'' section in entries at [http://uniprot.org UniProt.Org] offers MobiDB. MobiDB | * [http://biomine.cs.vcu.edu/servers/DEPICTER2/ DEPICTER2] (2023) predicts disorder and the '''functions''' of disordered regions<ref>PMID: 37140058</ref> <ref>PMID: 40728619</ref>. | ||
* [http://mobidb.bio.unipd.it/ MobiDB]. <!--The ''Structure'' section in entries at [http://uniprot.org UniProt.Org] offers MobiDB.--> MobiDB includes manually curated disorder data along with derived and predicted data. | |||
* [http://d2p2.pro/ D<sup>2</sup>P<sup>2</sup>]: "pre-computed disorder predictions on a large library of proteins from completely-sequenced genomes. ... statistical comparisons of the various prediction methods ...." | * [http://d2p2.pro/ D<sup>2</sup>P<sup>2</sup>]: "pre-computed disorder predictions on a large library of proteins from completely-sequenced genomes. ... statistical comparisons of the various prediction methods ...." | ||
