9r4z: Difference between revisions

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'''Unreleased structure'''


The entry 9r4z is ON HOLD
==Murine AA amyloid fibril morphology III (AA III)==
<StructureSection load='9r4z' size='340' side='right'caption='[[9r4z]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9r4z]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9R4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9R4Z FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9r4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9r4z OCA], [https://pdbe.org/9r4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9r4z RCSB], [https://www.ebi.ac.uk/pdbsum/9r4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9r4z ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE] Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
== Function ==
[https://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE] Major acute phase reactant. Apolipoprotein of the HDL complex.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The co-deposition of amyloid fibrils from different precursor proteins is a topic of increasing relevance for protein misfolding diseases. Using cryo-electron microscopy (cryo-EM), we here determined the structures of two serum amyloid A (SAA) protein-derived amyloid fibril morphologies that were extracted from a mouse strain that is primarily known to be associated with apolipoprotein A-II-derived amyloid fibrils. The two fibril morphologies show the same protomer conformation as in previously reported ex vivo amyloid fibrils from SAA protein but a different relative arrangement of fibril protein stacks. These data establish that serum amyloid A-derived amyloid fibrils share the same fibril protein fold in different mouse strains and disease contexts.


Authors: Andreotti, G., Schmidt, M., Faendrich, M.
Cryo-EM Observation of AA Amyloid Fibrils in Mouse Model of Systemic AApoAII Amyloidosis.,Andreotti G, Higuchi K, Schmidt M, Fandrich M J Mol Biol. 2025 Sep 11;437(24):169438. doi: 10.1016/j.jmb.2025.169438. PMID:40945578<ref>PMID:40945578</ref>


Description: Murine AA amyloid fibril morphology III (AA III)
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Faendrich, M]]
<div class="pdbe-citations 9r4z" style="background-color:#fffaf0;"></div>
[[Category: Andreotti, G]]
== References ==
[[Category: Schmidt, M]]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Andreotti G]]
[[Category: Faendrich M]]
[[Category: Schmidt M]]
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