9ug9: Difference between revisions

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'''Unreleased structure'''


The entry 9ug9 is ON HOLD  until Paper Publication
==The cryo-EM structure of 26S proteasome-Midnolin complex MB state==
 
<StructureSection load='9ug9' size='340' side='right'caption='[[9ug9]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9ug9]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UG9 FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ug9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ug9 OCA], [https://pdbe.org/9ug9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ug9 RCSB], [https://www.ebi.ac.uk/pdbsum/9ug9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ug9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MIDN_HUMAN MIDN_HUMAN] Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (PubMed:37616343). Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.[UniProtKB:D4AE48][UniProtKB:Q3TPJ7]<ref>PMID:37616343</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wang HY]]
[[Category: Xu WQ]]
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