Elongation factor 3D structures: Difference between revisions

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
*EF-Tu
*EF-Tu
**[[1ls2]] – yEF + Phe-tRNA – yeast – Cryo EM<BR />
**[[1ls2]] – yEF + Phe-tRNA – yeast – Cryo EM<BR />
**[[1efm]], [[1efc]], [[1dg1]], [[2fx3]], [[1etu]], [[5mi3]] – EcEF – ''Escherichia coli''<BR />
**[[1efm]], [[1efc]], [[1dg1]], [[2fx3]], [[1etu]], [[5mi3]] – EcEF – ''Escherichia coli''<BR />
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**[[5tbf]] – EF domain 2-3– ''Vibrio cholerae"
**[[5tbf]] – EF domain 2-3– ''Vibrio cholerae"
**[[5w76]], [[6htw]], [[6i8r]], [[7bbn]] – EF – synthetic<br />
**[[5w76]], [[6htw]], [[6i8r]], [[7bbn]] – EF – synthetic<br />
*''EF-Tu complex with antibiotics''
*''EF-Tu complex with antibiotics''
**[[1ob2]] - yEF + Phe-tRNA + antibiotic<BR />
**[[1ob2]] - yEF + Phe-tRNA + antibiotic<BR />
**[[4v8q]] - TtEF + antibiotic in 30S ribosome<BR />
**[[4v8q]] - TtEF + antibiotic in 30S ribosome<BR />
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**[[1d8t]], [[2hcj]], [[2hdn]], [[3u6b]], [[3u6k]], [[4g5g]], [[5jbq]], [[8fr3]] – EcEF + antibiotic<br />
**[[1d8t]], [[2hcj]], [[2hdn]], [[3u6b]], [[3u6k]], [[4g5g]], [[5jbq]], [[8fr3]] – EcEF + antibiotic<br />
**[[7st7]] – EcEF + antibiotic in 70S ribosome – Cryo EM<BR />
**[[7st7]] – EcEF + antibiotic in 70S ribosome – Cryo EM<BR />
*''EF-Tu complex with nucleotide''
*''EF-Tu complex with nucleotide''
**[[1d2e]] – bEF + GDP – bovine<BR />
**[[1d2e]] – bEF + GDP – bovine<BR />
**[[6eze]] – EcEF + GDP derivative<BR />
**[[6eze]] – EcEF + GDP derivative<BR />
Line 49: Line 43:
**[[6gfu]] – EF + GDP – synthetic<br />
**[[6gfu]] – EF + GDP – synthetic<br />
**[[7vok]] – MtEF + GDP – ''Mycobacterium tuberculosis''<br />
**[[7vok]] – MtEF + GDP – ''Mycobacterium tuberculosis''<br />
*''EF-Tu complex with protein''
*''EF-Tu complex with protein''
**[[3vmf]] – ApEF + translation termination factor<br />
**[[3vmf]] – ApEF + translation termination factor<br />
**[[3wy9]] – PhEF + L12 <br />
**[[3wy9]] – PhEF + L12 <br />
Line 61: Line 53:
**[[5v7y]] – EF + prolyl hydroxylase – ''Bacillus anthracis''<br />
**[[5v7y]] – EF + prolyl hydroxylase – ''Bacillus anthracis''<br />
**[[8xi2]] – EF in C* complex – ''Chlamydomonas reinhardtii'' – Cryo EM <br />
**[[8xi2]] – EF in C* complex – ''Chlamydomonas reinhardtii'' – Cryo EM <br />
*''EF-Tu with EF-Ts''
*''EF-Tu with EF-Ts''
**[[1xb2]] – bEF + EF-Ts - bovine<BR />
**[[1xb2]] – bEF + EF-Ts - bovine<BR />
**[[1f60]]  – yEF + EF-Ts C terminal<BR />
**[[1f60]]  – yEF + EF-Ts C terminal<BR />
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**[[1aip]] - TtEF + TtEF-Ts - ''Thermus thermophilus''<BR />
**[[1aip]] - TtEF + TtEF-Ts - ''Thermus thermophilus''<BR />
**[[7vmx]] – MtEF + MtEF-Ts <br />
**[[7vmx]] – MtEF + MtEF-Ts <br />
*''EF-Tu in the ribosome''
*''EF-Tu in the ribosome''
**[[7a5g]], [[7o9k]] – hEF in 80S mitoribosome + GMPPCP – Cryo EM<BR />
**[[7a5g]], [[7o9k]] – hEF in 80S mitoribosome + GMPPCP – Cryo EM<BR />
**[[3eq3]], [[3eq4]], [[5afi]] – EcEF in 80S ribosome – Cryo EM<BR />
**[[3eq3]], [[3eq4]], [[5afi]] – EcEF in 80S ribosome – Cryo EM<BR />
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**[[4v5g]], [[4v5l]], [[4v5p]], [[4v5q]], [[4v5r]], [[4v5s]] - TtEF in 70S ribosome
**[[4v5g]], [[4v5l]], [[4v5p]], [[4v5q]], [[4v5r]], [[4v5s]] - TtEF in 70S ribosome
**[[8v9l]] – EF in 70S ribosome – ''Mycobacterium smegmatis'' - Cryo EM<BR />
**[[8v9l]] – EF in 70S ribosome – ''Mycobacterium smegmatis'' - Cryo EM<BR />
*EF-SII
*EF-SII
**[[1tfi]] – hEF – human – NMR<BR />
**[[1tfi]] – hEF – human – NMR<BR />
**[[3ndq]] - hEF domain II<BR />
**[[3ndq]] - hEF domain II<BR />
Line 109: Line 95:
**[[2m1h]] – TbEF PWWP domain – ''Trypanosoma brucei'' – NMR<br />
**[[2m1h]] – TbEF PWWP domain – ''Trypanosoma brucei'' – NMR<br />
**[[7xgw]] – TbEF LN domain <br />
**[[7xgw]] – TbEF LN domain <br />
*EF-ELL2
*EF-ELL2
**[[2e5n]] – hEF N2 domain - NMR<BR />
**[[2e5n]] – hEF N2 domain - NMR<BR />
**[[5jw9]] – hEF + AFF4 peptide<br />
**[[5jw9]] – hEF + AFF4 peptide<br />
*EF-G
*EF-G
**[[1efg]], [[1elo]], [[1ktv]], [[1wdt]], [[2dy1]] – TtEF<BR />
**[[1efg]], [[1elo]], [[1ktv]], [[1wdt]], [[2dy1]] – TtEF<BR />
**[[4m1k]], [[4myt]], [[4myu]] – TtEF (mutant)<br />
**[[4m1k]], [[4myt]], [[4myu]] – TtEF (mutant)<br />
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**[[3zz0]], [[3zzt]], [[3zzu]] – SaEF (mutant) <BR />
**[[3zz0]], [[3zzt]], [[3zzu]] – SaEF (mutant) <BR />
**[[2mzw]] – SaEF domains III-V + FAR1<BR />
**[[2mzw]] – SaEF domains III-V + FAR1<BR />
*''EF-G in the ribosome''
*''EF-G in the ribosome''
**[[4v6x]], [[6vlz]], [[6z6m]], [[6z6n]], [[7a5k]], [[7w59]], [[7w5a]] – hEF in 80S ribosome – Cryo EM<BR />
**[[4v6x]], [[6vlz]], [[6z6m]], [[6z6n]], [[7a5k]], [[7w59]], [[7w5a]] – hEF in 80S ribosome – Cryo EM<BR />
**[[6vmi]] – hEF in 80S mitoribosome – Cryo EM<BR />
**[[6vmi]] – hEF in 80S mitoribosome – Cryo EM<BR />
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**[[7otc]] – EcEF in 70S ribosome + antibiotics – Cryo-EM<BR />
**[[7otc]] – EcEF in 70S ribosome + antibiotics – Cryo-EM<BR />
**[[8p2f]], [[8p2g]], [[8p2h]] – SaEF in 70S ribosome – Cryo-EM<BR />
**[[8p2f]], [[8p2g]], [[8p2h]] – SaEF in 70S ribosome – Cryo-EM<BR />
*EF-GreA/GreB
*EF-GreA/GreB
**[[2pn0]] – EF – ''Nitrosomonas europaea''<BR />
**[[2pn0]] – EF – ''Nitrosomonas europaea''<BR />
**[[2p4v]] – EcEF-GreB<br />
**[[2p4v]] – EcEF-GreB<br />
**[[1grj]] – EcEF-GreA<br />
**[[1grj]] – EcEF-GreA<br />
**[[6ri7]], [[6rin]] – EcEF-GreB + transcriptase + DNA + RNA – Cryo EM<br />
**[[6ri7]], [[6rin]] – EcEF-GreB + transcriptase + DNA + RNA – Cryo EM<br />
*EF-NusA
*EF-NusA
**[[1wcl]], [[1wcn]] – EcEF C terminal – NMR<BR />
**[[1wcl]], [[1wcn]] – EcEF C terminal – NMR<BR />
**[[2kwp]] - EcEF N terminal – NMR<BR />
**[[2kwp]] - EcEF N terminal – NMR<BR />
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**[[9f9u]] - EF – ''Saccharolobus solfataricus''<BR />
**[[9f9u]] - EF – ''Saccharolobus solfataricus''<BR />
**[[9fjl]] – NusA2 – ''Sulfolobus acidocaldarius''<BR />
**[[9fjl]] – NusA2 – ''Sulfolobus acidocaldarius''<BR />
*EF-P
*EF-P
**[[1ueb]] – TtEF<BR />
**[[1ueb]] – TtEF<BR />
**[[4v6a]] – TtEF in 70S ribosome<BR />
**[[4v6a]] – TtEF in 70S ribosome<BR />
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**[[6s8z]] – EF – ''Corynebacterium glutamicum'' <br />
**[[6s8z]] – EF – ''Corynebacterium glutamicum'' <br />
**[[5wxk]] – EF + EARP – ''Neisseria meningitidis''<br />
**[[5wxk]] – EF + EARP – ''Neisseria meningitidis''<br />
*EF-P-like
*EF-P-like
**[[8s8u]] – EcEFL
**[[8s8u]] – EcEFL
*EF-Ts
*EF-Ts
**[[2uz8]] – hEF (mutant)<br />
**[[2uz8]] – hEF (mutant)<br />
**[[1b64]] – hEF guanine exchange factor domain – NMR<BR />
**[[1b64]] – hEF guanine exchange factor domain – NMR<BR />
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**[[2yy3]] – PhEF <BR />
**[[2yy3]] – PhEF <BR />
**[[1tfe]] – TtEF<BR />
**[[1tfe]] – TtEF<BR />
*EF-1  
*EF-1  
 
**[[8b6z]], [[9p7k]] – hEF alpha in 80S ribosome – Cryo EM <br />
**[[8b6z]], [[9azs]] – hEF alpha in 80S ribosome – Cryo EM <br />
**[[5dqs]] – hEF β+γ <br />
**[[5dqs]] – hEF β+γ <br />
**[[5jpo]] – hEF γ+δ <br />
**[[5jpo]] – hEF γ+δ <br />
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**[[1nhy]] – yEF γ N terminal<br />
**[[1nhy]] – yEF γ N terminal<br />
**[[7csl]] – PhEF α+β <br />
**[[7csl]] – PhEF α+β <br />
 
*EF-1 homolog
**[[8b3d]], [[8b3f]], [[9bz0]], [[9er2]], [[9fd2]] - hEFH  in RNA pol II + TCR + RNA + DNA – Cryo EM<BR />
**[[8tvy]] - yEFH  in RNA pol II + TCR + RNA + DNA – Cryo EM<BR />
**[[5xog]] - EFH  in RNA pol II + Spt4/5 + RNA + DNA – ''Komagataella pastoris'' – Cryo EM<BR />
*EF-2
*EF-2
**[[4v4b]] - hEF  in 40S ribosome – Cryo EM<BR />
**[[4v4b]] - hEF  in 40S ribosome – Cryo EM<BR />
**[[8xsx]] - hEF  in 80S ribosome + tRNA + SERBP1 + drug – Cryo EM<BR />
**[[3j7p]] - pEF  in 80S ribosome – Cryo EM<BR />
**[[3j7p]] - pEF  in 80S ribosome – Cryo EM<BR />
**[[4cxg]], [[4cxh]] - rEF  in 40S ribosome – Cryo EM<BR />
**[[4cxg]], [[4cxh]] - rEF  in 40S ribosome – Cryo EM<BR />
**[[7ls1]], [[7ls2]] - mEF  in 80S ribosome – Cryo EM<BR />
**[[7ls1]], [[7ls2]] - mEF  in 80S ribosome – Cryo EM<BR />
**[[8q87]] - EF  in 80S ribosome + SERBP1 – chicken – Cryo EM<BR />
**[[4v6w]] - DmEF  in 40S ribosome – Cryo EM<BR />
**[[4v6w]] - DmEF  in 40S ribosome – Cryo EM<BR />
**[[7osm]] - yEF  in 80S ribosome<BR />
**[[7osm]] - yEF  in 80S ribosome<BR />
**[[5jup]], [[5jus]], [[5jut]], [[5juu]], [[6gq1]], [[7osa]] - yEF  in 80S ribosome – Cryo EM<BR />
**[[5jup]], [[5jus]], [[5jut]], [[5juu]], [[6gq1]], [[7osa]], [[8cku]], [[8cmj]], [[8t3e]], [[8t3f]], [[8xu8]] - yEF  in 80S ribosome – Cryo EM<BR />
**[[8yld]], [[8ylr]] – yEF-2 + EF-3  in 80S ribosome – Cryo EM<BR />
**[[8cdr]], [[8ceh]], [[8civ]] - yEF  in 80S ribosome + antibiotic – Cryo EM<BR />
**[[8eub]], [[8evs]], [[8ewb]] - yEF  in 80S ribosome + IRES – Cryo EM<BR />
**[[8evq]], [[8evr]], [[8t3a]], [[8t3b]], [[8t3c]], [[8t3d]] - yEF  in 80S ribosome + IRES + antibiotic – Cryo EM<BR />
**[[8umh]] - yEF  in pol II complex – Cryo EM<BR />
**[[1n0v]] – yEF<BR />
**[[1n0v]] – yEF<BR />
**[[1u2r]] – yEF + GDP<BR />
**[[1u2r]] – yEF + GDP<BR />
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**[[6u43]], [[6u44]] – MnEF (mutant)  + GMPPCP <BR />
**[[6u43]], [[6u44]] – MnEF (mutant)  + GMPPCP <BR />
**[[6q2d]] - EF + DPH2 – ''Methanobrevibacter smithii''<BR />
**[[6q2d]] - EF + DPH2 – ''Methanobrevibacter smithii''<BR />
*EF-3
*EF-3
**[[2ix3]] – yEF<BR />
**[[2ix3]] – yEF<BR />
**[[2iwh]] – yEF + ADPNP<BR />
**[[2iwh]] – yEF + ADPNP<BR />
**[[2iw3]] – yEF + ADP<BR />
**[[2iw3]] – yEF + ADP<BR />
**[[2ix8]], [[7b7d]] – yEF in 80S ribosome – Cryo EM<BR />
**[[2ix8]], [[7b7d]] – yEF in 80S ribosome – Cryo EM<BR />
*EF-4 (lepA)
*EF-4 (lepA)
**[[2ywh]], [[2ywe]], [[2ywf]], [[2ywg]] - AalepA  + nucleotide - ''Aquifex aeolicus''<BR />
**[[2ywh]], [[2ywe]], [[2ywf]], [[2ywg]] - AalepA  + nucleotide - ''Aquifex aeolicus''<BR />
**[[3cb4]] - EclepA  <BR />
**[[3cb4]] - EclepA  <BR />
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**[[5j8b]] - TtlepA  in 70S ribosome + GDPCP <BR />
**[[5j8b]] - TtlepA  in 70S ribosome + GDPCP <BR />
**[[4w2e]] - TtlepA  in 70S ribosome <BR />
**[[4w2e]] - TtlepA  in 70S ribosome <BR />
*EF-SelB
*EF-SelB
**[[5izk]], [[5izl]], [[5izm]] – hEF + GDP derivative<BR />
**[[5izk]], [[5izl]], [[5izm]] – hEF + GDP derivative<BR />
**[[1lva]] – MtEF C terminal – ''Moorella thermoacetica''<BR />
**[[1lva]] – MtEF C terminal – ''Moorella thermoacetica''<BR />
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**[[4ac9]] – MmEF + GDP<BR />
**[[4ac9]] – MmEF + GDP<BR />
**[[2pjp]] – EcEF + RNA<br />
**[[2pjp]] – EcEF + RNA<br />
*EF-Spt4 + EF-Spt5
*EF-Spt4 + EF-Spt5
**[[3h7h]] – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273<br />
**[[3h7h]] – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273<br />
**[[8p4d]], [[8p4f]], [[8w8f]] – hEF-Spt4 + EF-Spt5 in transcription complex – Cryo EM<br />
**[[7wbv]], [[7wbw]], [[7wbx]], [[9j0o]] – hEF-Spt4 + EF-Spt5 + EF-1-homolog in transcription complex + nucleosome – Cryo EM<br />
**[[6gmh]], [[6gml]] – hEF-Spt4 + EF-Spt5 + EF-Spt6 in transcription complex – Cryo EM<br />
**[[6gmh]], [[6gml]] – hEF-Spt4 + EF-Spt5 + EF-Spt6 in transcription complex – Cryo EM<br />
**[[8xrm]] – hEF-Spt4 + EF-Spt5 + EF-Spt6 + EF-1-homolog in RNA polymerase II elongation complex - CryoEM<br />
**[[5oik]] – bEF-Spt4 + EF-Spt5 + RNA polymerase II <br />
**[[5oik]] – bEF-Spt4 + EF-Spt5 + RNA polymerase II <br />
**[[7nkx]], [[7nky]] – yEF-Spt4 + EF-Spt5 + EF-Spt16 in RNA polymerase II elongation complex - CryoEM<br />
**[[7nkx]], [[7nky]] – yEF-Spt4 + EF-Spt5 + EF-Spt16 in RNA polymerase II elongation complex - CryoEM<br />
**[[8ram]], [[8rap]] – yEF-Spt4 + EF-Spt5 + EF-1 in RNA polymerase II elongation complex - CryoEM<br />
**[[2exu]] – yEF-Spt4 residues 1-99 + EF-Spt5 residues 285-375<br />
**[[2exu]] – yEF-Spt4 residues 1-99 + EF-Spt5 residues 285-375<br />
**[[4zn3]], [[4zn1]] – EF-Spt4 + EF-Spt5 – ''Methanocaldococcus jannaschii'' <br />
**[[4zn3]], [[4zn1]] – EF-Spt4 + EF-Spt5 – ''Methanocaldococcus jannaschii'' <br />
**[[5xon]], [[5xog]], [[6ir9]], [[6j4w]], [[6j4x]], [[6j4y]], [[6j4z]], [[6j50]], [[6j51]] – EF-Spt4 + EF-Spt5 + EF-Tfiis in RNA polymerase II elongation complex - ''Komagataella phaffii'' - Cryo EM<br />
**[[8p2i]] – PhEF-Spt4 + EF-Spt5 in RNA polymerase II elongation complex - CryoEM<br />
 
**[[8oki]] – PfEF-Spt4 + EF-Spt5 in RNA polymerase II elongation complex - CryoEM<br />
**[[5xon]], [[5xog]], [[6ir9]], [[6j4w]], [[6j4x]], [[6j4y]], [[6j4z]], [[6j50]], [[6j51]], [[8he5]], [[8jh2]] – EF-Spt4 + EF-Spt5 + EF-11 homolog in RNA polymerase II elongation complex - ''Komagataella phaffii'' - Cryo EM<br />
**[[9bct]], [[9bcu]] – EF-Spt4 + EF-Spt5 + EF-FTTA in RNA polymerase II elongation complex – ''Thermococcus kodakarensis'' - CryoEM<br />
*EF-Spt5
*EF-Spt5
 
**[[8p4c]], [[8p4e]], [[8uis]] – hEF-Spt5 in transcription complex – Cryo EM<br />
**[[2e6z]] – hEF KOW2 motif residues 420-471 – NMR<BR />
**[[2e6z]] – hEF KOW2 motif residues 420-471 – NMR<BR />
**[[2do3]] – hEF KOW3 motif residues 462-523 – NMR<BR />
**[[2do3]] – hEF KOW3 motif residues 462-523 – NMR<BR />
Line 290: Line 266:
**[[4ytl]] – yEF KOW2-KOW3 domain residues 534-632<br />
**[[4ytl]] – yEF KOW2-KOW3 domain residues 534-632<br />
**[[4ytk]] – yEF KOW1-linker domain residues 382-511<br />
**[[4ytk]] – yEF KOW1-linker domain residues 382-511<br />
**[[8jch]] – yEF in POL II complex – Cryo EM<br />
**[[8k5p]] – yEF in POL II complex + Rai1 – Cryo EM<br />
**[[8qsz]] – EF in POL II complex – fission yeast - Cryo EM<br />
**[[2exu]] – yEF<BR />
**[[2exu]] – yEF<BR />
*EF-Spt6
*EF-Spt6
**[[4z2n]] – hEF middle domain residues 644-930<br />
**[[4z2n]] – hEF middle domain residues 644-930<br />
**[[4z2m]] – hEF middle domain + histone H3.1 + histone H4<br />
**[[4z2m]] – hEF middle domain + histone H3.1 + histone H4<br />
**[[6gme]] – hEF SH2 domain residues 1317-1334<br />
**[[6gme]] – hEF SH2 domain residues 1317-1334<br />
**[[7oop]], [[7opc]], [[7opd]] – hEF-Spt6 in RNA polymerase II transcription complex – Cryo EM<br />
**[[7oop]], [[7opc]], [[7opd]], [[8oeu]], [[8oev]], [[8of0]] – hEF-Spt6 in RNA polymerase II transcription complex – Cryo EM<br />
**[[6ted]], [[7unc]], [[7und]] – pEF in RNA polymerase II transcription complex - CryoEM<br />
**[[6ted]], [[7unc]], [[7und]] – pEF in RNA polymerase II transcription complex - CryoEM<br />
**[[3psf]], [[3psi]] – yEF core domain residues 235-1259<BR />
**[[3psf]], [[3psi]] – yEF core domain residues 235-1259<BR />
Line 307: Line 284:
**[[6qtc]] – CgEF SH2 domain + Tyr phosphorylated CTD – NMR <br />
**[[6qtc]] – CgEF SH2 domain + Tyr phosphorylated CTD – NMR <br />
**[[2xp1]] – EF SH2 domain – ''Antonospora locustae'' <br />
**[[2xp1]] – EF SH2 domain – ''Antonospora locustae'' <br />
*EF-Spt16
*EF-Spt16
**[[5umu]], [[5umt]], [[5xm2]] – hEF<br />
**[[5umu]], [[5umt]], [[5xm2]] – hEF<br />
**[[5e5b]] - hEF  N-terminal<BR />
**[[5e5b]] - hEF  N-terminal<BR />
 
**[[8i17]] - hEF  + histone 2A + histone 2B<BR />
*EF-M2-1
*EF-M2-1
**[[5nkx]], [[5noh]] – EF core domain – human respiratory cyncytial virus<br />
**[[5nkx]], [[5noh]] – EF core domain – human respiratory cyncytial virus<br />
*EF-TEFM mitochondrial
*EF-TEFM mitochondrial
**[[5ol9]] - hEF N-terminal<br />
**[[5ol9]] - hEF N-terminal<br />
**[[5ol8]] - hEF C-terminal<br />
**[[5ol8]] - hEF C-terminal<br />
**[[5ola]] - hEF + RNA polymerase + RNA + DNA<br />
**[[5ola]] - hEF + RNA polymerase + RNA + DNA<br />
 
**[[8u8u]], [[8u8v]], [[9bdc]], [[9bdd]] - hEF + RNA polymerase + RNA + DNA – Cryo EM<br />
*EF-CA150
*EF-CA150
**[[2dod]], [[2doe]], [[2dof]], [[2e71]], [[2kiq]], [[2kis]] – hEF FF domain – NMR<BR />
**[[2dod]], [[2doe]], [[2dof]], [[2e71]], [[2kiq]], [[2kis]] – hEF FF domain – NMR<BR />
**[[3hfh]] – hEF FF domain<BR />
**[[3hfh]] – hEF FF domain<BR />
**[[2ysi]]– mEF WW domain - NMR<BR />
**[[2ysi]]– mEF WW domain - NMR<BR />
*Elongin A
*Elongin A
**[[4hfx]] – hEloA F-box domain<br />
**[[4hfx]] – hEloA F-box domain<br />
**[[6zuz]] – hEloA N-terminal<br />
**[[6zuz]] – hEloA N-terminal<br />
*Elongin C
*Elongin C
**[[5zb2]] – yEloC + Rad7<br />
**[[5zb2]] – yEloC + Rad7<br />
**[[1hv2]] - yEloC + von-Hippel Lindau disease tumor suppressor - NMR <br />
**[[1hv2]] - yEloC + von-Hippel Lindau disease tumor suppressor - NMR <br />
*Elongin BC complex
*Elongin BC complex
 
**[[1vcb]], [[8bdi]], [[8bdj]] – hEloBC + VHL<br />
**[[8ei3]] – hEloBC + VHL + peptide<br />
**[[1lqb]], [[1lm8]] – hEloBC + VHL + hypoxia inducible factor 1 α<br />
**[[1lqb]], [[1lm8]] – hEloBC + VHL + hypoxia inducible factor 1 α<br />
**[[6i7q]], [[6i7r]] – hEloBC + VHL + hypoxia inducible factor 2 α<br />
**[[6i7q]], [[6i7r]] – hEloBC + VHL + hypoxia inducible factor 2 α<br />
**[[7q2j]], [[8bb2]], [[8bb3]], [[8bb4]], [[8bb5]] – hEloBC + VHL + WD repeat-containing protein 5<br />
**[[7q2j]], [[8bb2]], [[8bb3]], [[8bb4]], [[8bb5]] – hEloBC + VHL + WD repeat-containing protein 5<br />
**[[7jto]], [[7jtp]] – hEloBC + VHL + WD repeat-containing protein 5 + inhibitor<br />
**[[7jto]], [[7jtp]] – hEloBC + VHL + WD repeat-containing protein 5 + inhibitor<br />
**[[7znt]] – hEloBC + VHL + bromodomain-containing protein 4<br />
**[[7znt]], [[8bdx]] – hEloBC + VHL + BRD4<br />
**[[3zrc]], [[3ztc]], [[3ztd]], [[3zun]], [[4awj]], [[4b95]], [[4b9k]], [[4bks]], [[4bkt]], [[4w9l]], [[4w9k]], [[4w9j]], [[4w9i]], [[4w9h]], [[4w9g]], [[4w9f]], [[4w9e]], [[4w9d]], [[4w9c]], [[5nw2]], [[5nw1]], [[5nw0]], [[5nvz]], [[5nvy]], [[5nvx]], [[5nvw]], [[5nvv]], [[6fmi]], [[6fmj]], [[6fmk]], [[6gfy]], [[8c13]] - hEloBC + VHL + inhibitor<br />
**[[8beb]], [[8ewv]] – hEloBC + VHL + BRD4 + ligand<br />
**[[8pc2]] – hEloBC + VHL + FKBP5<br />
**[[8fy0]], [[8fy1]], [[8fy2]] – hEloBC + VHL + Bcl-2<br />
**[[3zrc]], [[3ztc]], [[3ztd]], [[3zun]], [[4awj]], [[4b95]], [[4b9k]], [[4bks]], [[4bkt]], [[4w9l]], [[4w9k]], [[4w9j]], [[4w9i]], [[4w9h]], [[4w9g]], [[4w9f]], [[4w9e]], [[4w9d]], [[4w9c]], [[5nw2]], [[5nw1]], [[5nw0]], [[5nvz]], [[5nvy]], [[5nvx]], [[5nvw]], [[5nvv]], [[6fmi]], [[6fmj]], [[6fmk]], [[6gfy]], [[8bdl]], [[8bdm]], [[8bdn]], [[8bdo]], [[8c13]], [[8cqe]], [[8cqk]], [[8cql]], [[8p0f]], [[8qjs]], [[8zvj]], [[9bju]], [[9bol]], [[9gio]], [[9ipw]] - hEloBC + VHL + inhibitor<br />
**[[5t35]], [[6sis]] - hEloBC + VHL + BRD4<br />
**[[5t35]], [[6sis]] - hEloBC + VHL + BRD4<br />
**[[7khh]] - hEloBC + VHL + BRD4 + inhibitor<br />
**[[8qvu]] - hEloBC + VHL + Kras <br />
**[[7s4e]], [[7z6l]], [[7z76]], [[7z77]] - hEloBC + VHL + SMARCA2 + inhibitor<br /
**[[8qw6]], [[8qw7]] - hEloBC + VHL + Kras + inhibitor<br />
**[[7khh]], [[8bdt]] - hEloBC + VHL + BRD4 + inhibitor<br />
**[[8bds]] - hEloBC + VHL + BRD4 + inhibitor – Cryo EM<br />
**[[7s4e]], [[7z6l]], [[7z76]], [[7z77]], [[8g1q]] - hEloBC + VHL + SMARCA2 + inhibitor<br /
**[[4wqo]] - hEloBC + VHL + cullin-2 <br />
**[[4wqo]] - hEloBC + VHL + cullin-2 <br />
**[[6hr2]], [[6hay]], [[6hax]] - hEloBC + VHL + transcription activator  <br />
**[[6hr2]], [[6hay]], [[6hax]] - hEloBC + VHL + transcription activator  <br />
**[[8qjr]] - hEloBC + VHL + transcription activator + inhibitor <br />
**[[4ajy]] - hEloBC + hypoxia inducible factor peptide <br />
**[[4ajy]] - hEloBC + hypoxia inducible factor peptide <br />
**[[6gmr]], [[6gfx]], [[6bvb]] - hEloBC + VHL + hypoxia inducible factor peptide <br />
**[[6gmr]], [[6gfx]], [[6bvb]] - hEloBC + VHL + hypoxia inducible factor peptide <br />
**[[8ebn]] - hEloBC + kelch domain-containing protein<br />
**[[8sh2]] - hEloBC + kelch domain-containing protein – Cryo EM<br />
**[[9d1i]], [[9d1y]], [[9d1z]] - hEloBC + ubiquitin + kelch domain-containing protein<br />
**[[5n4w]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 + RBX1<br />
**[[5n4w]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 + RBX1<br />
**[[8ij1]], [[8wqg]], [[9j77]], [[9j78]] - hEloBC + cullin-2 + RBX1 + FEM-1 – Cryo EM<br />
**[[9j79]] - hEloBC + cullin-2 + RBX1 + FEM-1 + TOM20 – Cryo EM<br />
**[[9lky]] - hEloBC + cullin-2 + RBX1 + FEM-1 + choline phosphatase – Cryo EM<br />
**[[8jas]], [[8jau]], [[8jav]], [[8wqa]], [[8wqb]], [[8wqe]], [[8wqf]], [[8wqh]] - hEloBC + cullin-2 + RBX1 + FEM-1 + C-degron – Cryo EM<br />
**[[8jaq]], [[8jar]] - hEloBC + cullin-2 + RBX1 + APP + C-degron – Cryo EM<br />
**[[8je2]] - hEloBC + cullin-2 + folliculin-interacting protein + FEM-1 – Cryo EM<br />
**[[8je1]] - hEloBC + cullin-2 + BEX2 + FEM-1 – Cryo EM<br />
**[[8rwz]] - hEloBC + cullin-2 + RBX1 + BRD4 – Cryo EM<br />
**[[8wdk]] - hEloBC + VHL + cullin-2 + RBX1 + Wee – Cryo EM<br />
**[[8qu8]] - hEloBC + VHL + cullin-2 + RBX1 + Kras – Cryo EM<br />
**[[8q7r]] - hEloBC + cullin-2 + RBX1 + FEM-1 + ubiquitin + Nedd8 – Cryo EM<br />
**[[8r5h]] - hEloBC + cullin-2 + RBX1 + BRD4 + ubiquitin + ubiquitin conjugating enzyme  – Cryo EM<br />
**[[8pql]] - hEloBC + cullin-2 + RBX1 + FEM-1 + polyubiquitin + ubiquitin conjugating enzyme E2 – Cryo EM<br />
**[[8rx0]] - hEloBC + cullin-2 + RBX1 + CDC34 + ubiquitin + Nedd8 – Cryo EM<br />
**[[8ol1]] - hEloBC + nucleosome + cGAMP synthase + SSB-3 – Cryo EM<br />
**[[4n9f]] - hEloBC + VIF+ cullin-5 + CBF<br />
**[[4n9f]] - hEloBC + VIF+ cullin-5 + CBF<br />
**[[2ma9]] - hEloBC + VIF - NMR<br />
**[[2ma9]] - hEloBC + VIF - NMR<br />
**[[3zrf]], [[5lli]], [[6gmx]], [[6gmq]], [[6gmn]], [[6gfz]] - hEloBC + VHL<br />
**[[3zrf]], [[5lli]], [[6gmx]], [[6gmq]], [[6gmn]], [[6gfz]] - hEloBC + VHL<br />
**[[8vlb]] - hEloBC + VHL + CDO
**[[8vl9]] - hEloBC + VHL + CDO + molecular glue
**[[6zhc]] - hEloBC + VHL + Bcl-2-like protein<br />
**[[6zhc]] - hEloBC + VHL + Bcl-2-like protein<br />
**[[2c9w]], [[2izv]], [[2jz3]], [[5bo4]] – hEloBC + suppressor of cytokine signaling<br />
**[[2c9w]], [[2izv]], [[2jz3]], [[5bo4]] – hEloBC + suppressor of cytokine signaling<br />
**[[6c5x]], [[6i4x]], [[6i5n]], [[6i5j]] [[7m6t]] – hEloBC + suppressor of cytokine signaling + Gp130 peptide<br />
**[[6c5x]], [[6i4x]], [[6i5n]], [[6i5j]] [[7m6t]] – hEloBC + suppressor of cytokine signaling + Gp130 peptide<br />
**[[7zlm]], [[7zln]], [[7zlo]], [[7zlp]], [[7zlr]], [[7zls]] – hEloBC + suppressor of cytokine signaling + ligand<br />
**[[6i5n]], [[6i5j]] – hEloBC + suppressor of cytokine signaling + growth hormone receptor peptide<br />
**[[6i5n]], [[6i5j]] – hEloBC + suppressor of cytokine signaling + growth hormone receptor peptide<br />
**[[6i4x]] – hEloBC + suppressor of cytokine signaling + erythropoietin peptide<br />
**[[6i4x]] – hEloBC + suppressor of cytokine signaling + erythropoietin peptide<br />
**[[6p59]] - hEloBC + virion infectivity factor + CBF b<br />
**[[6p59]] - hEloBC + virion infectivity factor + CBF b<br />
**[[8fvi]], [[8fvj]] - hEloBC + virion infectivity factor + CBF beta – Cryo EM<br />
**[[7upn]] - hEloBC + virion infectivity factor + Ppiase – Cryo EM<br />
**[[8cx0]], [[8cx1]], [[8cx2]] - hEloBC + APOBEC + virion infectivity factor + CBF b + RNA – Cryo EM<br />
**[[8szk]] - hEloBC + PP2A+ virion infectivity factor + CBF b + RNA – Cryo EM<br />
**[[3zkj]] - hEloBC + ankyrin rep<br />
**[[3zkj]] - hEloBC + ankyrin rep<br />
**[[1vcb]] – hEloBC + VHL<br />
**[[8y1u]] - hEloBC + ankyrin repeat + LZTS1 degron
**[[3zng]] – hEloBC + ASB-9 <br />
**[[3zng]] – hEloBC + ASB-9 <br />
**[[6v9h]] – hEloBC + creatine kinase + ASB-9 – Cryo EM<br />
**[[6v9h]] – hEloBC + creatine kinase + ASB-9 – Cryo EM<br />
**[[6r6h]], [[6r7f]], [[6r7h]], [[6r7i]], [[6r7n]] – hEloBC in signalosome – Cryo EM<br />
**[[6r6h]], [[6r7f]], [[6r7h]], [[6r7i]], [[6r7n]] – hEloBC in signalosome – Cryo EM<br />
**[[9d8p]] – hEloBC + kelch domain-containing protein + ubiquitin – Cryo EM<br />
**[[2fnj]] - mEloBC + GUSTAVUS
**[[2fnj]] - mEloBC + GUSTAVUS
*Elongin ABC complex
**[[8oew]] – hEloABC + RNA Pol II + RNA + DNA – Cryo EM<br />
*Negative EF
**[[1x5p]], [[2bz2]], [[2jx2]] – hNELF-E RRM domain - NMR<br />
**[[5l3x]] – hNELF-A + hNELF-C/D <br />
**[[8jj6]] – hNELF-B + hNELF-C/D + hNELF-E <br />
**[[6gml]], [[8uha]], [[8uhd]], [[8uhg]], [[8uis]] – hNELF-F in Pol II complex – Cryo EM  <br />
**[[8ui0]], [[8w8e]] – hNELF-A + hNELF-B + hNELF-C/D + hNELF-E in Pol II complex – Cryo EM  <br />
**[[8uhg]] – hNELF-A + hNELF-B + hNELF-C/D + hNELF-E + Spt5 in Pol II complex – Cryo EM  <br />
**[[8rbx]], [[9j0n]], [[9j0o]], [[9j0p]] – hNELF-A + hNELF-B + hNELF-C/D + hNELF-E in Pol II complex + nucleosome – Cryo EM  <br />
}}
}}


[[Category:Topic Page]]
[[Category:Topic Page]]
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