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New page: left|200px<br /> <applet load="1z92" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z92, resolution 2.8Å" /> '''structure of interle...
 
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[[Image:1z92.gif|left|200px]]<br />
<applet load="1z92" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1z92, resolution 2.8&Aring;" />
'''structure of interleukin-2 with its alpha receptor'''<br />


==Overview==
==structure of interleukin-2 with its alpha receptor==
Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds, sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma, chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal, structure of a complex between human IL-2 and IL-2Ralpha, which interact, in a docking mode distinct from that of other cytokine receptor complexes., IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the, classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that, also serves as a binding site for antagonist drugs. With this complex, we, now have representative structures for each class of hematopoietic, cytokine receptor-docking modules.
<StructureSection load='1z92' size='340' side='right'caption='[[1z92]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1z92]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z92 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z92 OCA], [https://pdbe.org/1z92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z92 RCSB], [https://www.ebi.ac.uk/pdbsum/1z92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z92 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
== Function ==
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/1z92_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z92 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that also serves as a binding site for antagonist drugs. With this complex, we now have representative structures for each class of hematopoietic cytokine receptor-docking modules.


==Disease==
The structure of interleukin-2 complexed with its alpha receptor.,Rickert M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC Science. 2005 Jun 3;308(5727):1477-80. PMID:15933202<ref>PMID:15933202</ref>
Known diseases associated with this structure: Diabetes mellitus, insulin-dependent, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Severe combined immunodeficiency due to IL2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147680 147680]]


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1Z92 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Z92 OCA].
</div>
<div class="pdbe-citations 1z92" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
The structure of interleukin-2 complexed with its alpha receptor., Rickert M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC, Science. 2005 Jun 3;308(5727):1477-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15933202 15933202]
*[[Interleukin 3D structures|Interleukin 3D structures]]
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Boulanger, M.J.]]
[[Category: Boulanger MJ]]
[[Category: Garcia, K.C.]]
[[Category: Garcia KC]]
[[Category: Goriatcheva, N.]]
[[Category: Goriatcheva N]]
[[Category: Rickert, M.]]
[[Category: Rickert M]]
[[Category: Wang, X.Q.]]
[[Category: Wang XQ]]
[[Category: interleukin-2]]
[[Category: interleukin-2 alpha receptor]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:31:13 2007''
Retrieved from "https://proteopedia.org/1z92"