9r6o: Difference between revisions

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New page: '''Unreleased structure''' The entry 9r6o is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures
 
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'''Unreleased structure'''


The entry 9r6o is ON HOLD until Paper Publication
==Local refinement of the N-terminal domain (NTD) and receptor binding domain (RBD) from the Porcine hemagglutinating encephalomyelitis virus (PHEV) Spike in the closed conformation==
 
<StructureSection load='9r6o' size='340' side='right'caption='[[9r6o]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9r6o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_hemagglutinating_encephalomyelitis_virus Porcine hemagglutinating encephalomyelitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9R6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9R6O FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9r6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9r6o OCA], [https://pdbe.org/9r6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9r6o RCSB], [https://www.ebi.ac.uk/pdbsum/9r6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9r6o ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q2QKN3_9BETC Q2QKN3_9BETC] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099]  Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Porcine hemagglutinating encephalomyelitis virus]]
[[Category: Fernandez I]]
[[Category: Rey FA]]
Retrieved from "https://proteopedia.org/9r6o"