9r6v: Difference between revisions

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'''Unreleased structure'''


The entry 9r6v is ON HOLD  until Paper Publication
==Crystal structure of the DOC domain of the E3 ligase HECTD3==
 
<StructureSection load='9r6v' size='340' side='right'caption='[[9r6v]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9r6v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9R6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9R6V FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9r6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9r6v OCA], [https://pdbe.org/9r6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9r6v RCSB], [https://www.ebi.ac.uk/pdbsum/9r6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9r6v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HECD3_HUMAN HECD3_HUMAN] E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).[UniProtKB:Q3U487]<ref>PMID:18194665</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Esposito D]]
[[Category: Huber J]]
[[Category: Maslen S]]
[[Category: Rittinger K]]
Retrieved from "https://proteopedia.org/9r6v"