9v0h: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9v0h is ~~ON HOLD~~

==Crystal structure of human SIRT5 in complex with inhibitor 0904==

~~Authors~~: ~~Ying~~, L.L., ~~Jiang~~, Y.Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[9v0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V0H OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9V0H FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~human SIRT5~~ in ~~complex with inhibitor 0904~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.665Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EQQ:3-[[(~{E})-1-[3-[[2-(6-ethoxypyridin-3-yl)-5-[[(1~{R})-1-phenylpropyl]carbamoyl]pyrimidin-4-yl]amino]propylamino]-2-nitro-ethenyl]amino]propanoic+acid'>A1EQQ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: Jiang~~, Y.Y~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9v0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v0h OCA], [https://pdbe.org/9v0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v0h RCSB], [https://www.ebi.ac.uk/pdbsum/9v0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v0h ProSAT]</td></tr>

[[Category: Ying~~, L.L~~]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/SIR5_HUMAN SIR5_HUMAN] NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.<ref>PMID:18680753</ref> <ref>PMID:21908771</ref> <ref>PMID:24140062</ref> <ref>PMID:22076378</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Jiang YY]]

[[Category: Ying LL]]

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-'''Unreleased structure'''
-The entry 9v0h is ON HOLD
+==Crystal structure of human SIRT5 in complex with inhibitor 0904==
+<StructureSection load='9v0h' size='340' side='right'caption='[[9v0h]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
-Authors: Ying, L.L., Jiang, Y.Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9v0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V0H FirstGlance]. <br>
-Description: Crystal structure of human SIRT5 in complex with inhibitor 0904
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.665&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EQQ:3-[[(~{E})-1-[3-[[2-(6-ethoxypyridin-3-yl)-5-[[(1~{R})-1-phenylpropyl]carbamoyl]pyrimidin-4-yl]amino]propylamino]-2-nitro-ethenyl]amino]propanoic+acid'>A1EQQ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Jiang, Y.Y]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v0h OCA], [https://pdbe.org/9v0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v0h RCSB], [https://www.ebi.ac.uk/pdbsum/9v0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v0h ProSAT]</span></td></tr>
-[[Category: Ying, L.L]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SIR5_HUMAN SIR5_HUMAN] NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.<ref>PMID:18680753</ref> <ref>PMID:21908771</ref> <ref>PMID:24140062</ref> <ref>PMID:22076378</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Jiang YY]]
+[[Category: Ying LL]]