1z9q: Difference between revisions
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New page: left|200px<br /> <applet load="1z9q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z9q" /> '''Solution structure of SH3 domain of p40phox... |
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== | ==Solution structure of SH3 domain of p40phox== | ||
<StructureSection load='1z9q' size='340' side='right'caption='[[1z9q]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1z9q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z9Q FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z9q OCA], [https://pdbe.org/1z9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z9q RCSB], [https://www.ebi.ac.uk/pdbsum/1z9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z9q ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/NCF4_HUMAN NCF4_HUMAN] Defects in NCF4 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 3 (CGD3) [MIM:[https://omim.org/entry/613960 613960]. CGD3 is a disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:19692703</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NCF4_HUMAN NCF4_HUMAN] Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/1z9q_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z9q ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[NADPH oxidase 3D structures|NADPH oxidase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Adachi | [[Category: Adachi S]] | ||
[[Category: Fujioka | [[Category: Fujioka Y]] | ||
[[Category: Inagaki | [[Category: Inagaki F]] | ||
[[Category: Ogura | [[Category: Ogura K]] | ||
