9rib: Difference between revisions
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==Crystal structure of C278S mutant of mouse CDC14A== | |||
<StructureSection load='9rib' size='340' side='right'caption='[[9rib]], [[Resolution|resolution]] 1.62Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9rib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RIB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rib OCA], [https://pdbe.org/9rib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rib RCSB], [https://www.ebi.ac.uk/pdbsum/9rib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rib ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CC14A_MOUSE CC14A_MOUSE] Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis (By similarity). Required for normal hearing (PubMed:29293958).[UniProtKB:Q9UNH5]<ref>PMID:29293958</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Dong L]] | |||
[[Category: Friedman TB]] | |||
[[Category: Imtiaz A]] | |||
[[Category: Jackisch G]] | |||
[[Category: Knecht W]] | |||
[[Category: Logan DT]] | |||
[[Category: Shabbir K]] | |||
[[Category: Wilson E]] | |||
Latest revision as of 08:20, 11 December 2025
Crystal structure of C278S mutant of mouse CDC14A
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